Complement, natural antibodies, autoantibodies and tissue injury

被引：70

作者：

Fleming, SD

Tsokos, GC

机构：

[1] Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA

[2] Kansas State Univ, Div Biol, Manhattan, KS 66506 USA

[3] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA

来源：

AUTOIMMUNITY REVIEWS | 2006年 / 5卷 / 02期

关键词：

natural antibodies; tissue injury; autoantibodies; complement activation;

D O I：

10.1016/j.autrev.2005.09.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Activation of the classical complement pathway represents an effector mechanism of intestinal ischemia/reperfusion injury. Mice deficient in complement receptors I and 2 fail to produce a component of the natural antibody repertoire that binds to ischemia-conditioned tissues and activate complement. In contrast, mice prone to autoimmunity display accelerated and enhanced tissue injury that results from the binding of autoantibodies to injured tissues. Our experiments demonstrate that naturally occurring antibodies and autoantibodies mediate tissue injury only after an organ has been subjected to a stressor such as ischemia. Published by Elsevier B.V.

引用

收藏

页码：89 / 92

页数：4

相关论文

共 24 条

[1] Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen [J].

Ahearn, JM ;

Fischer, MB ;

Croix, D ;

Goerg, S ;

Ma, MH ;

Xia, JR ;

Zhou, XN ;

Howard, RG ;

Rothstein, TL ;

Carroll, MC .

IMMUNITY, 1996, 4 (03) :251-262

[2] Identification of the CD4+ T cell as a major pathogenic factor in ischemic acute renal failure [J].

Burne, MJ ;

Daniels, F ;

El Ghandour, A ;

Mauiyyedi, S ;

Colvin, RB ;

O'Connell, MP ;

Rabb, H .

JOURNAL OF CLINICAL INVESTIGATION, 2001, 108 (09) :1283-1290

[3] Antibody response to a T-dependent antigen requires B cell expression of complement receptors [J].

Croix, DA ;

Ahearn, JM ;

Rosengard, AM ;

Han, SH ;

Kelsoe, G ;

Ma, MH ;

Carroll, MC .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (04) :1857-1864

[4]

EISENBERG RA, 1989, CLIN EXP RHEUMATOL, V7, pS35

[5] Antiinflammatory effects of soluble complement receptor type 1 promote rapid recovery of ischemia/reperfusion injury in rat small intestine [J].

Eror, AT ;

Stojadinovic, A ;

Starnes, BW ;

Makrides, SC ;

Tsokos, GC ;

Shea-Donohue, T .

CLINICAL IMMUNOLOGY, 1999, 90 (02) :266-275

[6] THE CD19/CR2/TAPA-1 COMPLEX OF B-LYMPHOCYTES - LINKING NATURAL TO ACQUIRED-IMMUNITY [J].

FEARON, DT ;

CARTER, RH .

ANNUAL REVIEW OF IMMUNOLOGY, 1995, 13 :127-149

[7] Anti-phospholipid antibodies restore mesenteric ischemia/ reperfusion-induced injury in complement receptor 2 complement receptor 1-deficient mice [J].

Fleming, SD ;

Egan, RP ;

Chai, CY ;

Girardi, G ;

Holers, VM ;

Salmon, J ;

Monestier, M ;

Tsokos, GC .

JOURNAL OF IMMUNOLOGY, 2004, 173 (11) :7055-7061

[8] Accelerated ischemia/reperfusion-induced injury in autoimmunity-prone mice [J].

Fleming, SD ;

Monestier, M ;

Tsokost, GC .

JOURNAL OF IMMUNOLOGY, 2004, 173 (06) :4230-4235

[9] C5a causes limited, polymorphonuclear cell-independent, mesenteric ischemia/reperfusion-induced injury [J].

Fleming, SD ;

Mastellos, D ;

Karpel-Massler, G ;

Shea-Donohue, T ;

Lambris, JD ;

Tsokos, GC .

CLINICAL IMMUNOLOGY, 2003, 108 (03) :263-273

[10] C5 is required for CD49d expression on neutrophils and VCAM expression on vascular endothelial cells following mesenteric ischemia/reperfusion [J].

Fleming, SD ;

Anderson, J ;

Wilson, F ;

Shea-Donohue, T ;

Tsokos, GC .

CLINICAL IMMUNOLOGY, 2003, 106 (01) :55-64