Limited SP17 expression within tumors diminishes its therapeutic potential

被引：16

作者：

Gjerstorff, M. F. ^{[1
]}

Ditzel, H. J. ^{[1
,2
]}

机构：

[1] Univ So Denmark, Dept Canc & Inflammat Res, IMM, DK-5000 Odense C, Denmark

[2] Odense Univ Hosp, Dept Oncol, DK-5000 Odense, Denmark

来源：

TISSUE ANTIGENS | 2012年 / 80卷 / 06期

关键词：

cancer antigen; G antigen; immunotherapy; melanoma-associated antigen-A; sperm protein 17; SPERM PROTEIN-17 SP17; GENE-EXPRESSION; SPERM-PROTEIN-17; IMMUNOTHERAPY; LYMPHOCYTES; MYELOMA; ANTIGEN; TESTIS; CELLS;

D O I：

10.1111/tan.12015

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

In this study, we have investigated the expression of the tumor antigen sperm protein 17 (SP17) in a large panel of human cancers and compared it with the expression of two well-characterized families of tumor antigens, melanoma-associated antigen-A (MAGE-A) and G antigen (GAGE). We found that SP17 was expressed in many cancer types with an overall frequency of 12%. SP17 was most frequently expressed in a different set of cancer types than MAGE-A and GAGE antigens and rarely overlapped with these proteins. Importantly, SP17 expression was limited to a small number of scattered cancer cells in most positive tumors in contrast to MAGE-A and GAGE proteins, which were homogenously expressed in large foci. Our results suggest that SP17 may not be an optimal target for cancer vaccines.

引用

页码：523 / 527

页数：5

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