Two new nonacosanetriols from Ginkgo biloba sarcotesta

被引：21

作者：

Zhou, Guisheng ^{[1
]}

Yao, Xin ^{[1
]}

Tang, Yuping ^{[1
]}

Yang, Nianyun ^{[1
]}

Pang, Hanqing ^{[1
]}

Mo, Xuan ^{[1
]}

Zhu, Shaoqing ^{[1
]}

Su, Shulan ^{[1
]}

Qian, Dawei ^{[1
]}

Jin, Chun ^{[2
]}

Qin, Yong ^{[2
]}

Duan, Jin-ao ^{[1
]}

机构：

[1] Nanjing Univ Chinese Med, Jiangsu Key Lab High Technol TCM Formulae Res, Nanjing 210046, Jiangsu, Peoples R China

[2] Jiangsu Shenlong Pharmaceut Co Ltd, Yancheng 224200, Peoples R China

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 2012年 / 165卷 / 07期

关键词：

Ginkgo biloba; Sarcotesta; Fatty alcohol; Anticoagulative activity; Stereochemistry; TRUFFLE TUBER-INDICUM; ANNONACEOUS ACETOGENINS; LINOLEIC-ACID; DERIVATIVES; ASCOMYCETE; GLOBULIN; H-1-NMR; SEEDS; NMR;

D O I：

10.1016/j.chemphyslip.2012.08.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new fatty alcohols named as (7S,8R,11S)-nonacosanetriol (1) and (10R,12R,15S)-nonacosanetriol (2), along with eight known compounds including ginkgolic acid (3), hydroginkgolic acid (4), sciadopitysin (5), ginkgetin (6), isoginkgetin (7), ginkgolide A (8), ginkgolide B (9) and ginkgolide C (10) have been isolated from the petroleum ether extract of Ginkgo biloba sarcotesta. Their structures were elucidated by means of chemical and extensive spectroscopic analysis. The absolute stereochemistry of compounds 1 and 2 was elucidated on the spectroscopic analysis of the R- and S-MTPA esters. Compounds 1 and 2 exhibited slight activity of antithrombin and moderate activity of antiplatelet aggregation in vitro. This was the first report regarding the anticoagulative activities of biflavonoids in G. biloba, and isoginkgetin (7) showed significant antithrombin and antiplatelet aggregation activity. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：731 / 736

页数：6

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