Cell fate determination in the vertebrate retina

被引：805

作者：

Cepko, CL ^{[1
]}

Austin, CP ^{[1
]}

Yang, XJ ^{[1
]}

Alexiades, M ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,DEPT GENET,BOSTON,MA 02115

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1996年 / 93卷 / 02期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1073/pnas.93.2.589

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In the vertebrate central nervous system, the retina has been a useful model for studies of cell fate determination. Recent results from studies conducted in vitro and in vivo suggest a model of retinal development in which both the progenitor cells and the environment change over time. The model is based upon the notion that the mitotic cells within the retina change in their response properties, or ''competence'', during development. These changes presage the ordered appearance of distinct cell types during development and appear to be necessary for the production of the distinct cell types. As the response properties of the cells change, so too do the environmental signals that the cells encounter. Together, intrinsic properties and extrinsic cues direct the choice of cell fate.

引用

页码：589 / 595

页数：7

共 59 条

[1] PLASTICITY AND DIFFERENTIATION OF EMBRYONIC RETINAL CELLS AFTER TERMINAL MITOSIS [J].