ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease

被引：59

作者：

Carlsson, Lena M. S. ^{[1
,2
]}

Jacobson, Peter ^{[1
,2
]}

Walley, Andrew ^{[3
]}

Froguel, Philippe ^{[3
,4
]}

Sjostrom, Lars ^{[1
,2
]}

Svensson, Per-Arne ^{[1
,2
]}

Sjoholm, Kajsa ^{[1
,2
]}

机构：

[1] Sahlgrens Acad, Dept Mol & Clin Med, S-41345 Gothenburg, Sweden

[2] Sahlgrens Acad, Ctr Cardiovasc & Metab Res, S-41345 Gothenburg, Sweden

[3] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Sect Genom Med, London SW7 2AZ, England

[4] Inst Pasteur, CNRS 8090, Inst Biol, F-59019 Lille, France

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 382卷 / 02期

基金：

瑞典研究理事会; 英国惠康基金;

关键词：

Adipose tissue; Human; Obesity; Activin receptor-like kinase; Expression; Microarray; ACTIVIN-B; HUMAN ADIPOCYTES; GENE-EXPRESSION; RECEPTOR ALK7; SIGNAL; PATHWAY; CELLS;

D O I：

10.1016/j.bbrc.2009.03.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human adipose tissue is a major site of expression of inhibin beta B (INHBB) which homodimerizes to form the novel adipokine activin B. Our aim was to determine if molecules needed for a local action of activin B are expressed in adipose tissue. Microarray analysis showed that adipose tissue expressed activin type I and If receptors and that the expression of activin receptor-like kinase 7 (ALK7) was adipose tissue specific. In obesity discordant siblings from the SOS Sib Pair Study, adipose tissue ALK7 expression was higher in lean (n = 90) compared to obese (n = 90) subjects (p = 4 x 10(-31)). Adipose tissue ALK7 expression correlated with several measures of body fat, carbohydrate metabolism and lipids. In addition, ALK7 and INHBB expression correlated but only in lean subjects and ill Subjects with normal glucose tolerance. We conclude that activin B may have local effects in adipose tissue and thereby influence obesity and its comorbidities. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：309 / 314

页数：6

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