Down-regulation of IGF-1/IGF-1R in hippocampus of rats with vascular dementia

被引：70

作者：

Gong, Xiuqun ^{[1
]}

Ma, Minmin ^{[1
]}

Fan, Xinying ^{[1
]}

Li, Mingquan ^{[1
]}

Liu, Qian ^{[1
]}

Liu, Xinfeng ^{[1
]}

Xu, Gelin ^{[1
]}

机构：

[1] Nanjin Univ, Dept Neurol, Jinling Hosp, Sch Med, Nanjing 210002, Jiangsu, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2012年 / 513卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Chronic ischemia; Vascular dementia (VaD); Learning and memory; IGF-1/IGF-1R signaling; GROWTH-FACTOR-I; IMPROVES COGNITIVE FUNCTION; CENTRAL-NERVOUS-SYSTEM; PROTEIN-KINASE-B; ARTERY OCCLUSION; HYPOXIA-ISCHEMIA; INSULIN; EXPRESSION; SURVIVAL; BRAIN;

D O I：

10.1016/j.neulet.2012.01.077

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Insulin-like growth factor-1 (IGF-1) has been demonstrated to have neuroprotective effects, but little is known concerning its role in vascular dementia (VaD). This study aimed to evaluate expression of IGF-1 signaling in hippocampus in rat model of VaD, and probe the underlying mechanisms. Permanent occlusion of bilateral common carotid arteries (2-VO) was used as VaD model. Learning and memory functions were declined significantly in 2-VO rats, and these impairments were further deteriorated with the prolongation of 2-VO treatment. IGF-1, IGF-1 receptor (IGF-1R), total Akt and phosphorylated Akt (p-Akt) were all measured at 1, 2 and 4 months following 2-VO injury. Compared with controls, IGF-1, IGF-1 mRNA and p-Akt expression were significantly decreased in hippocampus of 2-VO rats. However, changes of IGF-1R and total Akt levels were not significant. These results suggest that down-regulation of IGF-1 and p-Akt may contribute to the impairments of learning and memory functions after 2-VO. IGF-1/IGF-1R signaling system may involved in the onset and development of VaD. (c) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：20 / 24

页数：5

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