New functional families (FunFams) in CATH to improve the mapping of conserved functional sites to 3D structures

被引：162

作者：

Sillitoe, Ian ^{[1
]}

Cuff, Alison L. ^{[1
]}

Dessailly, Benoit H. ^{[2
]}

Dawson, Natalie L. ^{[1
]}

Furnham, Nicholas ^{[3
]}

Lee, David ^{[1
]}

Lees, Jonathan G. ^{[1
]}

Lewis, Tony E. ^{[1
]}

Studer, Romain A. ^{[1
]}

Rentzsch, Robert ^{[4
]}

Yeats, Corin ^{[1
]}

Thornton, Janet M. ^{[3
]}

Orengo, Christine A. ^{[1
]}

机构：

[1] UCL, Inst Struct & Mol Biol, Div Biosci, London WC1E 6BT, England

[2] Natl Inst Biomed Innovat, Lab Bioinformat, Osaka, Japan

[3] European Bioinformat Inst, EMBL Outstn Hinxton, Cambridge CB10 1SD, England

[4] Robert Koch Inst, Res Grp Bioinformat, D-13353 Berlin, Germany

来源：

NUCLEIC ACIDS RESEARCH | 2013年 / 41卷 / D1期

基金：

美国国家卫生研究院; 英国生物技术与生命科学研究理事会; 英国惠康基金; 瑞士国家科学基金会;

关键词：

ENZYME; RESOURCE; GENE3D; CLASSIFICATION; SUPERFAMILIES; ANNOTATION; DIVERSITY; EVOLUTION; PROTEINS; GENOMICS;

D O I：

10.1093/nar/gks1211

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

CATH version 3.5 (Class, Architecture, Topology, Homology, available at http://www.cathdb.info/) contains 173 536 domains, 2626 homologous superfamilies and 1313 fold groups. When focusing on structural genomics (SG) structures, we observe that the number of new folds for CATH v3.5 is slightly less than for previous releases, and this observation suggests that we may now know the majority of folds that are easily accessible to structure determination. We have improved the accuracy of our functional family (FunFams) sub-classification method and the CATH sequence domain search facility has been extended to provide FunFam annotations for each domain. The CATH website has been redesigned. We have improved the display of functional data and of conserved sequence features associated with FunFams within each CATH superfamily.

引用

页码：D490 / D498

页数：9

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