Genetic contributions to addiction

被引:149
作者
Crabbe, JC [1 ]
机构
[1] Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland Alcohol Res Ctr, Portland, OR 97201 USA
[2] VA Med Ctr, Portland, OR USA
关键词
substance abuse; animal models; QTL; gene-environment interaction; transgenic;
D O I
10.1146/annurev.psych.53.100901.135142
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
Even the most extreme environmentalists along the nature-nurture continuum in psychology now acknowledge that genes often contribute to individual differences in behavior. Behavioral traits are complex, reflecting the aggregate effects of many genes. These genetic effects are interactive, inter se and with the environments in which they are expressed. Human studies of addictive behaviors have clearly implicated both environmental and genetic influences. This review selects drug dependence as a paradigmatic addiction, and further, concentrates on the extensive literature with genetic animal models. Both traditional studies with inbred strains and selected lines and studies exploiting the new molecularly based technologies of the genomics era are discussed. Future directions for further contribution of animal models studies to our understanding of the brain dysregulations characteristic of addictions are identified.
引用
收藏
页码:435 / 462
页数:28
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