The use of selective estrogen receptor modulators on bone health in men

被引：17

作者：

Wong, Sok Kuan ^{[1
]}

Mohamad, Nur-Vaizura ^{[1
]}

Jayusman, Putri Ayu ^{[1
]}

Shuid, Ahmad Nazrun ^{[1
]}

Ima-Nirwana, Soelaiman ^{[1
]}

Chin, Kok-Yong ^{[1
]}

机构：

[1] Univ Kebangsaan Malaysia, Fac Med, Dept Pharmacol, Kuala Lumpur, Malaysia

来源：

AGING MALE | 2019年 / 22卷 / 02期

关键词：

Osteoporosis; tamoxifen; raloxifene; lasofoxifene; toremifene; ANDROGEN DEPRIVATION THERAPY; MINERAL DENSITY; BREAST-CANCER; LASOFOXIFENE CP-336,156; MECHANICAL-PROPERTIES; POSTMENOPAUSAL WOMEN; PROSTATE-CANCER; SKELETAL SYSTEM; DRUG-THERAPY; MALE RATS;

D O I：

10.1080/13685538.2018.1448058

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Selective estrogen receptor modulators (SERMs) represent a class of drugs that act as agonist or antagonist for estrogen receptor in a tissue-specific manner. The SERMs drugs are initially used for the prevention and treatment of osteoporosis in postmenopausal women. Bone health in prostate cancer patients has become a significant concern, whereby patients undergo androgen deprivation therapy is often associated with deleterious effects on bone. Previous preclinical and epidemiological findings showed that estrogens play a dominant role in improving bone health as compared to testosterone in men. Therefore, this evidence-based review aims to assess the available evidence derived from animal and human studies on the effects of SERMs on the male skeletal system. The effects of SERMs on bone mineral density (BMD)/content (BMC), bone histomorphometry, bone turnover, bone strength and fracture risk have been summarized in this review.

引用

页码：89 / 101

页数：13

共 81 条

[1]

Bone Health and Bone-Targeted Therapies for Nonmetastatic Prostate Cancer A Systematic Review and Meta-analysis [J].

Alibhai, Shabbir M. H. ;

Zukotynski, Katherine ;

Walker-Dilks, Cindy ;

Emmenegger, Urban ;

Finelli, Antonio ;

Morgan, Scott C. ;

Hotte, Sebastien J. ;

Tomlinson, George A. ;

Winquist, Eric .

ANNALS OF INTERNAL MEDICINE, 2017, 167 (05) :341-+

[2]

Selective toxic effects of tamoxifen on osteoclasts: Comparison with the effects of oestrogen [J].

Arnett, TR ;

Lindsay, R ;

Kilb, JM ;

Moonga, BS ;

Spowage, M ;

Dempster, DW .

JOURNAL OF ENDOCRINOLOGY, 1996, 149 (03) :503-508

[3]

HORMONE REPLACEMENT AND CANCER [J].

BARRETTCONNOR, E .

BRITISH MEDICAL BULLETIN, 1992, 48 (02) :345-355

[4]

Evidence for cell-specific changes with age in expression of oestrogen receptor (ER) α and β in bone fractures from men and women [J].

Batra, GS ;

Hainey, L ;

Freemont, AJ ;

Andrew, G ;

Saunders, PTK ;

Hoyland, JA ;

Braidman, IP .

JOURNAL OF PATHOLOGY, 2003, 200 (01) :65-73

[5]

Mortality Risk Associated With Low-Trauma Osteoporotic Fracture and Subsequent Fracture in Men and Women [J].

Bliuc, Dana ;

Nguyen, D. Nguyen ;

Milch, Vivienne E. ;

Nguyen, Tuan V. ;

Eisman, John A. ;

Center, Jacqueline R. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2009, 301 (05) :513-521

[6]

Secular Changes in Postfracture Outcomes Over 2 Decades in Australia: A Time-Trend Comparison of Excess Postfracture Mortality in Two Birth Controls Over Two Decades [J].

Bliuc, Dana ;

Tran, Thach ;

Alarkawi, Dunia ;

Nguyen, Tuan V. ;

Eisman, John A. ;

Center, Jacqueline R. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2016, 101 (06) :2475-2483

[7]

The Impact of Nonhip Nonvertebral Fractures in Elderly Women and Men [J].

Bliuc, Dana ;

Nguyen, Tuan V. ;

Eisman, John A. ;

Center, Jacqueline R. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2014, 99 (02) :415-423

[8]

The role of activation functions 1 and 2 of estrogen receptor-α for the effects of estradiol and selective estrogen receptor modulators in male mice [J].

Borjesson, Anna E. ;

Farman, Helen H. ;

Engdahl, Cecilia ;

Koskela, Antti ;

Sjogren, Klara ;

Kindblom, Jenny M. ;

Stubelius, Alexandra ;

Islander, Ulrika ;

Carlsten, Hans ;

Antal, Maria Cristina ;

Krust, Andree ;

Chambon, Pierre ;

Tuukkanen, Juha ;

Lagerquist, Marie K. ;

Windahl, Sara H. ;

Ohlsson, Claes .

JOURNAL OF BONE AND MINERAL RESEARCH, 2013, 28 (05) :1117-1126

[9]

Raloxifen prevents bone loss in castrated male mice [J].

Broulik, P. D. ;

Broulikova, K. .

PHYSIOLOGICAL RESEARCH, 2007, 56 (04) :443-447

[10]

Tamoxifen prevents bone loss in castrated male mice [J].

Broulik, PD .

HORMONE AND METABOLIC RESEARCH, 2000, 32 (05) :181-184

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