Pyrrocidines A and B, new antibiotics produced by a filamentous fungus

被引：127

作者：

He, HY ^{[1
]}

Yang, HY ^{[1
]}

Bigelis, R ^{[1
]}

Solum, EH ^{[1
]}

Greenstein, M ^{[1
]}

Carter, GT ^{[1
]}

机构：

[1] Wyeth Ayerst Res, Nat Prod Chem, Pearl River, NY 10965 USA

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 09期

关键词：

D O I：

10.1016/S0040-4039(02)00099-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

Pyrrocidines A (1) and B (2), two new antibiotics, containing rare 13-membered macrocycles, were isolated from the fermentation broth of a fungus, LL-Cyan426. Pyrrocidine A (1) exhibited potent activity against Gram-positive bacteria, including drug-resistant strains. The structures of these compounds were established using spectroscopic methods. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1633 / 1636

页数：4

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