Metabolites of the "Smoke tree", Dalea spinosa, potentiate antibiotic activity against multidrug-resistant Staphylococcus aureus

被引：56

作者：

Belofsky, G ^{[1
]}

Carreno, R

Lewis, K

Ball, A

Casadei, G

Tegos, GP

机构：

[1] Univ Tulsa, Dept Chem & Biochem, Tulsa, OK 74101 USA

[2] Northeastern Univ, Dept Biol, Boston, MA 02115 USA

[3] Univ Teramo, Dept Food Sci, Sch Vet Med, I-64100 Teramo, Italy

[4] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Dermatol,Wellman Labs Photomed, Boston, MA 02114 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 02期

关键词：

D O I：

10.1021/np058057s

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new 2-arylbenzofuran aldehydes (1 and 2) and three known phenolic compounds (3-5) were isolated from organic extracts of Dalea spinosa. These compounds were evaluated for their intrinsic antimicrobial activity and. their ability to perform as multidrug-resistance inhibitors by potentiating the activity of known antimicrobials against a variety of pathogenic microorganisms. Compound 1 and its acetate derivative 6 exhibited no direct antimicrobial activity but enhanced the effect of the weak plant antimicrobial berberine when tested against Staphylococcus aureus. Additional potentiation assays with S. aureus overexpression and knockout isogenic efflux mutants for the NorA pump were done in order to assess whether the potentiating effects were associated with inhibition of this known pump mechanism.

引用

页码：261 / 264

页数：4

共 24 条

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