共 70 条
The role of stroma in immune recognition and destruction of well-established solid tumors
被引:91
作者:

Yu, P
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

Rowley, DA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

Fu, YX
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

Schreiber, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Chicago, IL 60637 USA
机构:
[1] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA
[2] Univ Chicago, Comm Immunol, Chicago, IL 60637 USA
关键词:
D O I:
10.1016/j.coi.2006.01.004
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Well-established solid tumors (at least 14 days old and >1 cm in average dianneter) are extremely difficult to eradicate immunologically in mice. Most cancer patients that seek medical attention bear primary or metastatic tumors that have grown for longer and that are larger than the tumors we call established. Therefore, focusing research on the problems of rejecting well-established mouse tumors might help in the development of novel concepts and protocols for destroying tumors in patients. A particular problem with established cancers is that even when treatments induce temporary regression, cancer often recurs. Recent studies suggest that manipulation of the stromal microenvironment of these tumors can induce immune recognition and regression. Furthermore, targeting cancer cells as well as tumor stroma for immune destruction might be needed to prevent recurrence.
引用
收藏
页码:226 / 231
页数:6
相关论文
共 70 条
[1]
TGF-β1 attenuates the acquisition and expression of effector function by tumor antigen-specific human memory CD8 T cells
[J].
Ahmadzadeh, M
;
Rosenberg, SA
.
JOURNAL OF IMMUNOLOGY,
2005, 174 (09)
:5215-5223

Ahmadzadeh, M
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Surg Branch, NIH, Bethesda, MD 20892 USA NCI, Surg Branch, NIH, Bethesda, MD 20892 USA

Rosenberg, SA
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Surg Branch, NIH, Bethesda, MD 20892 USA NCI, Surg Branch, NIH, Bethesda, MD 20892 USA
[2]
CD8+T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells
[J].
Antony, PA
;
Piccirillo, CA
;
Akpinarli, A
;
Finkelstein, SE
;
Speiss, PJ
;
Surman, DR
;
Palmer, DC
;
Chan, CC
;
Klebanoff, CA
;
Overwijk, WW
;
Rosenberg, SA
;
Restifo, NP
.
JOURNAL OF IMMUNOLOGY,
2005, 174 (05)
:2591-2601

Antony, PA
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Div Surg, Ctr Canc Res, NIH, Bethesda, MD 20892 USA NCI, Div Surg, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

Piccirillo, CA
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Div Surg, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

Akpinarli, A
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Div Surg, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

Finkelstein, SE
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Div Surg, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

Speiss, PJ
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Div Surg, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

Surman, DR
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Div Surg, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

Palmer, DC
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Div Surg, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

Chan, CC
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Div Surg, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

Klebanoff, CA
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Div Surg, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

Overwijk, WW
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Div Surg, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

Rosenberg, SA
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Div Surg, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

Restifo, NP
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Div Surg, Ctr Canc Res, NIH, Bethesda, MD 20892 USA
[3]
c-kit+ FcR+ myelocytes are increased in cancer and prevent the proliferation of fully cytolytic T cells in the presence of immune serum
[J].
Beck, C
;
Schreiber, K
;
Schreiber, H
;
Rowley, DA
.
EUROPEAN JOURNAL OF IMMUNOLOGY,
2003, 33 (01)
:19-28

Beck, C
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Chicago, Dept Pathol, Chicago, IL 60637 USA Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

Schreiber, K
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Chicago, Dept Pathol, Chicago, IL 60637 USA Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

Schreiber, H
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Chicago, Dept Pathol, Chicago, IL 60637 USA Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

Rowley, DA
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Chicago, Dept Pathol, Chicago, IL 60637 USA Univ Chicago, Dept Pathol, Chicago, IL 60637 USA
[4]
Tumor-stroma interactions
[J].
Bhowmick, NA
;
Moses, HL
.
CURRENT OPINION IN GENETICS & DEVELOPMENT,
2005, 15 (01)
:97-101

Bhowmick, NA
论文数: 0 引用数: 0
h-index: 0
机构:
Vanderbilt Univ, Sch Med, Dept Canc Biol, Nashville, TN 37232 USA Vanderbilt Univ, Sch Med, Dept Canc Biol, Nashville, TN 37232 USA

Moses, HL
论文数: 0 引用数: 0
h-index: 0
机构:
Vanderbilt Univ, Sch Med, Dept Canc Biol, Nashville, TN 37232 USA Vanderbilt Univ, Sch Med, Dept Canc Biol, Nashville, TN 37232 USA
[5]
The role of tumor stroma in the interaction between tumor and immune system
[J].
Blankenstein, T
.
CURRENT OPINION IN IMMUNOLOGY,
2005, 17 (02)
:180-186

Blankenstein, T
论文数: 0 引用数: 0
h-index: 0
机构: Max Delbruck Ctr Mol Med, D-13092 Berlin, Germany
[6]
THICKNESS, CROSS-SECTIONAL AREAS AND DEPTH OF INVASION IN PROGNOSIS OF CUTANEOUS MELANOMA
[J].
BRESLOW, A
.
ANNALS OF SURGERY,
1970, 172 (05)
:902-&

BRESLOW, A
论文数: 0 引用数: 0
h-index: 0
[7]
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3
[J].
Chen, WJ
;
Jin, WW
;
Hardegen, N
;
Lei, KJ
;
Li, L
;
Marinos, N
;
McGrady, G
;
Wahl, SM
.
JOURNAL OF EXPERIMENTAL MEDICINE,
2003, 198 (12)
:1875-1886

Chen, WJ
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Inst Dent & Craniofacial Res, Oral Infect & Immun Branch, Cellular Immunol Sect, NIH, Bethesda, MD 20892 USA Natl Inst Dent & Craniofacial Res, Oral Infect & Immun Branch, Cellular Immunol Sect, NIH, Bethesda, MD 20892 USA

Jin, WW
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Inst Dent & Craniofacial Res, Oral Infect & Immun Branch, Cellular Immunol Sect, NIH, Bethesda, MD 20892 USA Natl Inst Dent & Craniofacial Res, Oral Infect & Immun Branch, Cellular Immunol Sect, NIH, Bethesda, MD 20892 USA

Hardegen, N
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Inst Dent & Craniofacial Res, Oral Infect & Immun Branch, Cellular Immunol Sect, NIH, Bethesda, MD 20892 USA Natl Inst Dent & Craniofacial Res, Oral Infect & Immun Branch, Cellular Immunol Sect, NIH, Bethesda, MD 20892 USA

Lei, KJ
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Inst Dent & Craniofacial Res, Oral Infect & Immun Branch, Cellular Immunol Sect, NIH, Bethesda, MD 20892 USA Natl Inst Dent & Craniofacial Res, Oral Infect & Immun Branch, Cellular Immunol Sect, NIH, Bethesda, MD 20892 USA

Li, L
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Inst Dent & Craniofacial Res, Oral Infect & Immun Branch, Cellular Immunol Sect, NIH, Bethesda, MD 20892 USA Natl Inst Dent & Craniofacial Res, Oral Infect & Immun Branch, Cellular Immunol Sect, NIH, Bethesda, MD 20892 USA

Marinos, N
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Inst Dent & Craniofacial Res, Oral Infect & Immun Branch, Cellular Immunol Sect, NIH, Bethesda, MD 20892 USA Natl Inst Dent & Craniofacial Res, Oral Infect & Immun Branch, Cellular Immunol Sect, NIH, Bethesda, MD 20892 USA

McGrady, G
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Inst Dent & Craniofacial Res, Oral Infect & Immun Branch, Cellular Immunol Sect, NIH, Bethesda, MD 20892 USA Natl Inst Dent & Craniofacial Res, Oral Infect & Immun Branch, Cellular Immunol Sect, NIH, Bethesda, MD 20892 USA

Wahl, SM
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Inst Dent & Craniofacial Res, Oral Infect & Immun Branch, Cellular Immunol Sect, NIH, Bethesda, MD 20892 USA Natl Inst Dent & Craniofacial Res, Oral Infect & Immun Branch, Cellular Immunol Sect, NIH, Bethesda, MD 20892 USA
[8]
NEUTROPHILS ARE ESSENTIAL FOR EARLY ANTI-LISTERIA DEFENSE IN THE LIVER, BUT NOT IN THE SPLEEN OR PERITONEAL-CAVITY, AS REVEALED BY A GRANULOCYTE-DEPLETING MONOCLONAL-ANTIBODY
[J].
CONLAN, JW
;
NORTH, RJ
.
JOURNAL OF EXPERIMENTAL MEDICINE,
1994, 179 (01)
:259-268

CONLAN, JW
论文数: 0 引用数: 0
h-index: 0
机构: Trudeau Institute, Inc., Saranac Lake, NY

NORTH, RJ
论文数: 0 引用数: 0
h-index: 0
机构: Trudeau Institute, Inc., Saranac Lake, NY
[9]
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
[J].
Curiel, TJ
;
Coukos, G
;
Zou, LH
;
Alvarez, X
;
Cheng, P
;
Mottram, P
;
Evdemon-Hogan, M
;
Conejo-Garcia, JR
;
Zhang, L
;
Burow, M
;
Zhu, Y
;
Wei, S
;
Kryczek, I
;
Daniel, B
;
Gordon, A
;
Myers, L
;
Lackner, A
;
Disis, ML
;
Knutson, KL
;
Chen, LP
;
Zou, WP
.
NATURE MEDICINE,
2004, 10 (09)
:942-949

Curiel, TJ
论文数: 0 引用数: 0
h-index: 0
机构: Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70112 USA

Coukos, G
论文数: 0 引用数: 0
h-index: 0
机构: Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70112 USA

Zou, LH
论文数: 0 引用数: 0
h-index: 0
机构: Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70112 USA

Alvarez, X
论文数: 0 引用数: 0
h-index: 0
机构: Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70112 USA

Cheng, P
论文数: 0 引用数: 0
h-index: 0
机构: Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70112 USA

Mottram, P
论文数: 0 引用数: 0
h-index: 0
机构: Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70112 USA

Evdemon-Hogan, M
论文数: 0 引用数: 0
h-index: 0
机构: Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70112 USA

Conejo-Garcia, JR
论文数: 0 引用数: 0
h-index: 0
机构: Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70112 USA

Zhang, L
论文数: 0 引用数: 0
h-index: 0
机构: Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70112 USA

Burow, M
论文数: 0 引用数: 0
h-index: 0
机构: Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70112 USA

Zhu, Y
论文数: 0 引用数: 0
h-index: 0
机构: Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70112 USA

Wei, S
论文数: 0 引用数: 0
h-index: 0
机构: Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70112 USA

Kryczek, I
论文数: 0 引用数: 0
h-index: 0
机构: Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70112 USA

Daniel, B
论文数: 0 引用数: 0
h-index: 0
机构: Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70112 USA

Gordon, A
论文数: 0 引用数: 0
h-index: 0
机构: Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70112 USA

Myers, L
论文数: 0 引用数: 0
h-index: 0
机构: Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70112 USA

Lackner, A
论文数: 0 引用数: 0
h-index: 0
机构: Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70112 USA

Disis, ML
论文数: 0 引用数: 0
h-index: 0
机构: Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70112 USA

Knutson, KL
论文数: 0 引用数: 0
h-index: 0
机构: Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70112 USA

Chen, LP
论文数: 0 引用数: 0
h-index: 0
机构: Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70112 USA

Zou, WP
论文数: 0 引用数: 0
h-index: 0
机构:
Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70112 USA Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70112 USA
[10]
Chemokines - Chemokines and cell migration in secondary lymphoid organs
[J].
Cyster, JG
.
SCIENCE,
1999, 286 (5447)
:2098-2102

Cyster, JG
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA