Biomarker Modelling of Early Molecular Changes in Alzheimer's Disease

被引：7

作者：

Paterson, Ross W. ^{[1
,2
]}

Toombs, Jamie ^{[3
]}

Slattery, Catherine F. ^{[1
]}

Schott, Jonathan M. ^{[1
]}

Zetterberg, Henrik ^{[3
,4
,5
]}

机构：

[1] UCL Inst Neurol, Dementia Res Ctr, Dept Neurodegenerat, London, England

[2] UCL Inst Neurol, Dementia Res Grp, London WC1N 3BG, England

[3] UCL Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, England

[4] Sahlgrens Univ Hosp, Clin Neurochem Lab, Dept Psychiat & Neurochem, Gothenburg, Sweden

[5] Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Gothenburg, Sweden

来源：

MOLECULAR DIAGNOSIS & THERAPY | 2014年 / 18卷 / 02期

基金：

瑞典研究理事会;

关键词：

AMYLOID PRECURSOR PROTEIN; MILD COGNITIVE IMPAIRMENT; CEREBROSPINAL-FLUID BIOMARKERS; GENOME-WIDE ASSOCIATION; VISININ-LIKE PROTEIN-1; CORTICAL BRAIN BIOPSY; A-BETA; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; OXIDATIVE STRESS;

D O I：

10.1007/s40291-013-0069-9

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

The preclinical phase of Alzheimer's disease (AD) occurs years, possibly decades, before the onset of clinical symptoms. Being able to detect the very earliest stages of AD is critical to improving understanding of AD biology, and identifying individuals at greatest risk of developing clinical symptoms with a view to treating AD pathophysiology before irreversible neurodegeneration occurs. Studies of dominantly inherited AD families and longitudinal studies of sporadic AD have contributed to knowledge of the earliest AD biomarkers. Here we appraise this evidence before reviewing novel, particularly fluid, biomarkers that may provide insights into AD pathogenesis and relate these to existing hypothetical disease models.

引用

页码：213 / 227

页数：15

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