Clathrin-independent endocytosis: A unique platform for cell signaling and PM remodeling

被引：145

作者：

Donaldson, Julie G. ^{[1
]}

Porat-Shliom, Natalie ^{[1
]}

Cohen, Lee Ann ^{[1
]}

机构：

[1] NHLBI, LCB, NIH, Bethesda, MD 20892 USA

来源：

CELLULAR SIGNALLING | 2009年 / 21卷 / 01期

关键词：

Arf6; Clathrin-independent; Endocytosis; Macropinocytosis; Phosphoinositides; Signaling; Src; Ras; PLASMA-MEMBRANE; PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE; CONSTITUTIVE MACROPINOCYTOSIS; DOWNSTREAM ACTIVATION; NEUROENDOCRINE CELLS; RECEPTOR ENDOCYTOSIS; RECYCLING PATHWAY; EXCHANGE FACTORS; ARF6; RECRUITS; RAS PROTEINS;

D O I：

10.1016/j.cellsig.2008.06.020

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

There is increasing interest in endocytosis that occurs independently of clathrin coats and the fates of membrane proteins internalized by this mechanism. The appearance of clathrin-independent endocytic and membrane recycling pathways seems to vary with different cell types and cargo molecules. In this review we focus on studies that have been performed using HeLa and COS cells as model systems for understanding this membrane trafficking system. These endosomal membranes contain signaling molecules including H-Ras, Rac1, Arf6 and Rab proteins, and a lipid environment rich in cholesterol and PIP2 providing a unique platform for cell signaling. Furthermore, activation of some of these signaling molecules (H-Ras, Rac and Arf6) can switch the constitutive form of clathrin-independent endocytosis into a stimulated one, associated with PM ruffling and macropinocytosis. Published by Elsevier Inc.

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页码：1 / 6

页数：6

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