Integrin signaling revisited

被引：278

作者：

Schwartz, MA ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Vasc Biol, La Jolla, CA 92037 USA

来源：

TRENDS IN CELL BIOLOGY | 2001年 / 11卷 / 12期

关键词：

D O I：

10.1016/S0962-8924(01)02152-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Adhesion to the extracellular matrix (ECM) is a crucial regulator of cell function, and it is now well established that signaling by integrins mediates many of these effects. Ten years of research has seen integrin signaling advance on many fronts towards a molecular understanding of the control mechanisms. Most striking is the merger with studies of other receptors, the cytoskeleton and mechanical forces within the general field of signaling networks.

引用

页码：466 / 470

页数：5

共 62 条

[1]

ADAMS JC, 1993, DEVELOPMENT, V117, P1183

[2] Matrix survival signaling:: From fibronectin via focal adhesion kinase to c-Jun NH2-terminal kinase [J].

Almeida, EAC ;

Ilic, D ;

Han, Q ;

Hauck, CR ;

Jin, F ;

Kawakatsu, H ;

Schlaepfer, DD ;

Damsky, CH .

JOURNAL OF CELL BIOLOGY, 2000, 149 (03) :741-754

[3]

Aplin AE, 1999, J CELL SCI, V112, P695

[4] The compliance of collagen gels regulates transforming growth factor-β induction of α-smooth muscle actin in fibroblasts [J].

Arora, PD ;

Narani, N ;

McCulloch, CAG .

AMERICAN JOURNAL OF PATHOLOGY, 1999, 154 (03) :871-882

[5] Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity [J].

Bianchi, E ;

Denti, S ;

Granata, A ;

Bossi, G ;

Geginat, J ;

Villa, A ;

Rogge, L ;

Pardi, R .

NATURE, 2000, 404 (6778) :617-+

[6] A mechanism for modulation of cellular responses to VEGF: Activation of the integrins [J].

Byzova, TV ;

Goldman, CK ;

Pampori, N ;

Thomas, KA ;

Bett, A ;

Shattil, SJ ;

Plow, EF .

MOLECULAR CELL, 2000, 6 (04) :851-860

[7] Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain [J].

Chen, RY ;

Kim, O ;

Li, M ;

Xiong, XS ;

Guan, JL ;

Kung, HJ ;

Chen, HG ;

Shimizu, Y ;

Qiu, Y .

NATURE CELL BIOLOGY, 2001, 3 (05) :439-444

[8] Extracellular matrix rigidity causes strengthening of integrin-cytoskeleton linkages [J].

Choquet, D ;

Felsenfeld, DP ;

Sheetz, MP .

CELL, 1997, 88 (01) :39-48

[9] Rho-stimulated contractility drives the formation of stress fibers and focal adhesions [J].

ChrzanowskaWodnicka, M ;

Burridge, K .

JOURNAL OF CELL BIOLOGY, 1996, 133 (06) :1403-1415

[10] Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK [J].

del Pozo, MA ;

Price, LS ;

Alderson, NB ;

Ren, XD ;

Schwartz, MA .

EMBO JOURNAL, 2000, 19 (09) :2008-2014

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