Papillomaviruses:: different genes have different histories

被引：111

作者：

García-Vallvé, S

Alonso, A

Bravo, IG

机构：

[1] Deutsch Krebsforschungszentrum, D-69120 Heidelberg, Germany

[2] URV, Evolutionary Genom Grp, Dept Biochem & Biotechnol, Tarragona 43007, Spain

来源：

TRENDS IN MICROBIOLOGY | 2005年 / 13卷 / 11期

关键词：

D O I：

10.1016/j.tim.2005.09.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Papillomaviruses (PVs) infect stratified squamous epithelia in vertebrates. Some PVs are associated with different types of cancer and with certain benign lesions. It has been assumed that PVs coevolved with their hosts. However, recently it has been shown that different regions of the genome have different evolutionary histories. The PV genome has a modular nature and appeared after the addition of pre-existent blocks. This order of appearance in the PV genome is evident today in the different evolutionary rates of the different genes, with new genes - E5, E6 and E7 - diverging faster than old genes - E1, E2, L2 and L1. Here, we propose an evolutionary framework aiming to integrate genome evolution, PV biology and epidemiology of PV infections.

引用

页码：514 / 521

页数：8

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