Modified Ling-Gui-Zhu-Gan decoction combined with short-term fasting improves therapeutic response in type 2 diabetic patients

被引：18

作者：

Chen, Dingsheng ^{[1
]}

Li, Chenying ^{[1
,2
]}

Michalsen, Andreas ^{[2
]}

Kessler, Christian ^{[2
]}

Huang, Yingjuan ^{[1
]}

Meng, Jun ^{[1
]}

Ke, Bin ^{[1
]}

Wang, Yuanyuan ^{[1
]}

Zhang, Junjie ^{[1
]}

Qin, Jian ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou 510275, Guangdong, Peoples R China

[2] Charite Univ Med Ctr Berlin, D-14109 Berlin, Germany

来源：

EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE | 2012年 / 4卷 / 03期

关键词：

Very-low-calorie-diets; Fasting; Chinese medicine; Diabetes mellitus; Glycemic control; Herbal medicine; LOW-CALORIE DIET; OBESE NIDDM; MELLITUS;

D O I：

10.1016/j.eujim.2011.12.011

中图分类号：

R [医药、卫生];

学科分类号：

100218 [急诊医学];

摘要：

Objective: To evaluate the effects of a Traditional Chinese Medicine herbal decoction (modified Ling-Gui-Zhu-Gan decoction) combined with short-term fasting/very-low-calorie-diet (VLCD) on the therapeutic response in type 2 diabetes mellitus (T2DM) patients. Materials and methods: A randomized controlled pilot-study was conducted with 60 T2DM patients (age 52.1 +/- 13.4 y, BMI 25.7 +/- 3.7 kg/m(2)) with a lack of glycemic control. Patients were randomly allocated to the intervention group (n = 30) or the control group (n = 30). All patients received in-hospital treatment for one week followed by lifestyle recommendation. Patients in the intervention group participated in a 5-day modified fasting/VLCD combined with an intake of Ling-Gui-Zhu-Gan decoction. Patients in the control group received standard treatment only. Outcomes were assessed at baseline and at 3-months. Results: Fasting plasma-glucose, 2-h plasma-glucose after oral glucose tolerance-test, HbA(1C), and the use of anti-diabetic medication decreased significantly in the intervention group compared to the control group after three months. Body weight also decreased significantly. Conclusions: Acombined integrative treatment approach including fasting/VLCD and a Traditional Chinese Medicine decoction might be superior to standard treatment in T2DM patients. This therapeutic concept should be further evaluated. (C) 2012 Elsevier GmbH. All rights reserved.

引用

页码：E309 / E314

页数：6

共 17 条

[1]

Effects and clinical potential of very-low-calorie diets (VLCDs) in type 2 diabetes [J].