Variability in the response of HDL cholesterol to exercise training in the HERITAGE Family Study

被引:77
作者
Leon, AS
Gaskill, SE
Rice, T
Bergeron, J
Gagnon, J
Rao, DC
Skinner, JS
Wilmore, JH
Bouchard, C
机构
[1] Univ Minnesota, Div Kinesiol, Lab Physiol Hyg & Exercise Sci, Minneapolis, MN 55455 USA
[2] Univ Montana, Dept Hlth & Human Performance, Missoula, MT 59812 USA
[3] Washington Univ, Sch Med, Div Biostat, St Louis, MO USA
[4] CHUL, Res Ctr, Lipid Res Ctr, Quebec City, PQ, Canada
[5] CHUL, Lab Rech Endocrinol Mol, Quebec City, PQ, Canada
[6] Washington Univ, Sch Med, Dept Genet & Psychiat, St Louis, MO USA
[7] Indiana Univ, Dept Kinesiol, Bloomington, IN USA
[8] Texas A&M Univ, Dept Hlth & Kinesiol, College Stn, TX USA
[9] Louisiana State Univ, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA
关键词
blood lipids; HDL; exercise training; HERITAGE Family Study;
D O I
10.1055/s-2002-19270
中图分类号
G8 [体育];
学科分类号
04 ; 0403 ;
摘要
In the HERITAGE Family Study, 675 sedentary, healthy, white and black men and women, aged 17 to 65 years, performed 20 weeks of supervised cycle ergometer exercise at the same relative intensity and weekly volume. As a group, subjects had normal mean baseline lipid levels for North Americans with the exception of below average high density lipoprotein cholesterol (HDL-C) levels. A significant mean increase in plasma HDL-C of 3.6% was observed; however, there was marked variability in responsiveness to training, ranging from a mean 9.3 % decrease in Quartile 1 of HDL-C response to a mean 18 % increase in Quartile 4 (P < 0.0001 by ANOVA). Parallel changes in HDL2-C and HDL3-C, apolipoprotein A-1 levels, and lipoprotein lipase activity were noted across quartiles. The change in HIDL-C across quartiles was inversely related to baseline HDL-C (p < 0.0001) and to changes with training in plasma triglycerides (p = 0.0007). No significant differences in HDL-C response were observed across quartiles by sex, race, age, or increase in VO(2)max with training; however, weak positive associations were observed with age-adjusted education level and with reduction in abdominal fat and increase in VO(2)max at the ventilatory threshold following training. Multivariate regression analysis including baseline variables and training responses only accounted for 15.5 % of the variability in the HIDL-C response to training. Thus, marked variability was found in the HIDL-C response to the same endurance exercise training stimulus with only a modest amount of the response predictable by identified nongenetic factors.
引用
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页码:1 / 9
页数:9
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