Inhibitory activity of monoamine oxidase by coumarins from Peucedanum japonicum

被引：38

作者：

Huong, DTL

Choi, HC

Rho, TC

Lee, HS

Lee, MK

Kim, YH ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

[2] KRIBB, Taejon 305600, South Korea

[3] Chungbuk Natl Univ, Coll Pharm, Cheongju 361763, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 1999年 / 22卷 / 03期

关键词：

Peucedanum japonicum; umbelliferae; coumarins; monoamine oxidase;

D O I：

10.1007/BF02976373

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four coumarins were isolated from chloroform extract of the root of Peucedanum japonicum and identified as praeruptorin A (1), xanthotoxin (2), psoralen (3) and bergapten (4) on the basis of spectroscopic methods. The inhibitory activities of these coumarins on monoamine oxidase prepared by mouse brain were tested. The IC, values of them were shown to be 27.4 mu M (1), 40.7 mu M (2), 35.8 mu M (3), and 13.8 mu M (4), in vitro.

引用

页码：324 / 326

页数：3

共 17 条

[1] Coumarins and antiplatelet aggregation constituents from formosan Peucedanum japonicum [J].