The role of FOXP3 in disease progression in colorectal cancer patients

被引：47

作者：

Grimmig, Tanja ^{[1
]}

Kim, Mia ^{[1
]}

Germer, Christoph-Thomas ^{[1
]}

Gasser, Martin ^{[1
]}

Waaga-Gasser, Ana Maria ^{[1
]}

机构：

[1] Univ Wurzburg, Dept Surg 1, D-97070 Wurzburg, Germany

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 06期

关键词：

colorectal cancer; FOXP3; prognosis; REGULATORY T-CELLS; IMMUNE EVASION; EXPRESSION;

D O I：

10.4161/onci.24521

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The transcription factor forkhead box P3 (FOXP3) has been identified as a marker of CD4(+)CD25(+) regulatory T cells and is a key determinant of their immunosuppressive functions. FOXP3 has indeed been shown to limit antitumor immune responses during tumor progression. In addition, by expressing FOXP3, tumor cells may evade effector T-cell responses.

引用

页数：2

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