Triterpene and diterpene inhibitors of pyruvate dehydrogenase kinase (PDK)

被引：35

作者：

Aicher, TD ^{[1
]}

Damon, RE ^{[1
]}

Koletar, J ^{[1
]}

Vinluan, CC ^{[1
]}

Brand, LJ ^{[1
]}

Gao, JP ^{[1
]}

Shetty, SS ^{[1
]}

Kaplan, EL ^{[1
]}

Mann, WR ^{[1
]}

机构：

[1] Novartis Inst Biomed Res, Metab & Cardiovasc Dis Res, Summit, NJ 07901 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(99)00380-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several oximes of triterpenes with a 17-beta hydroxyl and abietane derivatives are inhibitors of pyruvate dehydrogenase kinase (PDK) activity. The oxime 12 and dehydroabietyl amine 2 exhibit a blood glucose lowering effect in the diabetic ob/ob mouse after a single oral dose of 100 mu mol/kg. However, the mechanism of the blood glucose lowering effect is likely unrelated to PDK inhibition. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2223 / 2228

页数：6

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