Taste receptor-like cells in the rat gut identified by expression of alpha-gustducin

被引：321

作者：

Hofer, D ^{[1
]}

Puschel, B ^{[1
]}

Drenckhahn, D ^{[1
]}

机构：

[1] UNIV WURZBURG,INST ANAT,D-97070 WURZBURG,GERMANY

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1996年 / 93卷 / 13期

关键词：

chemoreception; rat stomach; intestine; brush cells; epithelium;

D O I：

10.1073/pnas.93.13.6631

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The alpha-subunit of the trimeric G-protein complex specific for taste receptor cells of the tongue, alpha-gustducin, is described here to be also expressed in the stomach and intestine. The alpha-gustducin-containing cells were identified as brush cells that are scattered throughout the surface epithelium of the gut and share structural features of taste receptor cells of the tongue, These findings provide clues to the long-sought molecular and cellular basis for chemoreception in the gut.

引用

收藏

页码：6631 / 6634

页数：4

相关论文

共 17 条

[1] STOMACH NO SYNTHESIS [J].

BENJAMIN, N ;

ODRISCOLL, F ;

DOUGALL, H ;

DUNCAN, C ;

SMITH, L ;

GOLDEN, M ;

MCKENZIE, H .

NATURE, 1994, 368 (6471) :502-502

[2] ENTEROCHROMAFFIN CELLS OF THE DIGESTIVE-SYSTEM - CELLULAR SOURCE OF GUANYLIN, A GUANYLATE CYCLASE-ACTIVATING PEPTIDE [J].

CETIN, Y ;

KUHN, M ;

KULAKSIZ, H ;

ADERMANN, K ;

BARGSTEN, G ;

GRUBE, D ;

FORSSMANN, WG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (08) :2935-2939

[3] PRODUCTION OF POLYCLONAL ANTIBODIES AGAINST PROTEINS AND PEPTIDES [J].

DRENCKHAHN, D ;

JONS, T ;

SCHMITZ, F .

METHODS IN CELL BIOLOGY, VOL 37: ANTIBODIES IN CELL BIOLOGY, 1993, 37 :7-56

[4]

DRENCKHAHN D, 1986, J CELL BIOL, V102, P1943

[5] IDENTIFICATION OF BRUSH CELLS IN THE ALIMENTARY AND RESPIRATORY SYSTEM BY ANTIBODIES TO VILLIN AND FIMBRIN [J].

HOFER, D ;

DRENCKHAHN, D .

HISTOCHEMISTRY, 1992, 98 (04) :237-242

[6]

JOHNSON LR, 1993, PHYSL GASTROINTESTIN, V2

[7]

JOHNSON LR, 1993, PHYSL GASTROINTESTIN, V1

[8] COLOCALIZATION OF CYTOKERATIN-18 AND VILLIN IN TYPE-III ALVEOLAR CELLS (BRUSH CELLS) OF THE RAT LUNG [J].

KASPER, M ;

HOFER, D ;

WOODCOCKMITCHELL, J ;

MIGHELI, A ;

ATTANASIO, A ;

RUDOLF, T ;

MULLER, M ;

DRENCKHAHN, D .

HISTOCHEMISTRY, 1994, 101 (01) :57-62

[9]

KITAGAWA H, 1990, J PHARMACOL EXP THER, V253, P1133

[10] NITRIC-OXIDE SYNTHASE AND NADP-LINKED GLUCOSE-6-PHOSPHATE-DEHYDROGENASE ARE CO-LOCALIZED IN BRUSH CELLS OF RAT STOMACH AND PANCREAS [J].

KUGLER, P ;

HOFER, D ;

MAYER, B ;

DRENCKHAHN, D .

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1994, 42 (10) :1317-1321