Extracellular vesicles as an emerging mechanism of cell-to-cell communication

被引：326

作者：

Tetta, Ciro ^{[1
,2
]}

Ghigo, Ezio ^{[1
,2
]}

Silengo, Lorenzo ^{[1
,2
]}

Deregibus, Maria Chiara ^{[1
,2
]}

Camussi, Giovanni ^{[1
,2
]}

机构：

[1] Univ Turin, Translat Ctr Regenerat Med, Dept Mol Biotechnol & Hlth Sci, Turin, Italy

[2] Univ Turin, Translat Ctr Regenerat Med, Dept Med Sci & Fresenius Med Care, Turin, Italy

来源：

ENDOCRINE | 2013年 / 44卷 / 01期

关键词：

Exosomes; Microvesicles; MRNA; MicroRNA; TUMOR-DERIVED MICROVESICLES; HORIZONTAL TRANSFER; MESSENGER-RNAS; EXOSOMES; MICRORNA; ROLES; BIOMARKERS; SECRETION; CD63; ASSOCIATION;

D O I：

10.1007/s12020-012-9839-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The concept that extracellular vesicles may act as paracrine/endocrine effectors is based on the evidence that they are able to transport bioactive molecules between cells, either within a defined microenvironment or remotely, by entering the biologic fluids. Extracellular vesicles, including exosomes and microvesicles, may deliver lipids and various functional transcripts, released from the cell of origin, to target cells. Since extracellular vesicles contain defined patterns of mRNA, microRNA, long non-coding RNA, and occasionally genomic DNA, they may transfer genetic information which induces transient or persistent phenotypic changes in recipient cells. In this review, we will discuss potential physiologic and pathological implications of extracellular vesicles, as well as the diagnostic and therapeutic opportunities that they may provide.

引用

页码：11 / 19

页数：9

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