Ubiquitination-proteasome system: A new player in the pathogenesis of psoriasis and clinical implications

被引：41

作者：

Yang, Luting ^{[1
]}

Guo, Weinan ^{[1
]}

Zhang, Shaolong ^{[1
]}

Wang, Gang ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Xijing Hosp, Dept Dermatol, 127 West Changle Rd, Xian 710032, Shaanxi, Peoples R China

来源：

JOURNAL OF DERMATOLOGICAL SCIENCE | 2018年 / 89卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Ubiquitination; Proteasome; Psoriasis; Treatment; NF-KAPPA-B; ROR-GAMMA-T; LUPUS-ERYTHEMATOSUS; IMMUNE-RESPONSES; RHEUMATOID-ARTHRITIS; POLYUBIQUITIN CHAINS; TRANSCRIPTION FACTOR; PROTEIN-DEGRADATION; SUSCEPTIBILITY GENE; 20S PROTEASOME;

D O I：

10.1016/j.jdermsci.2017.12.002

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100227 [皮肤病学];

摘要：

Ubiquitination is an important post-translational modification that regulates a myriad of biological processes such as inflammation, immune response, cell differentiation and proliferation. During the last decade, progress in proteomics contributed to the identification of new E3 ligases and their substrates. Hence, deregulated ubiquitination events are found to be involved in several inflammatory disorders, exemplifying by systemic lupus erythematosus (SLE), type 1 diabetes, rheumatoid arthritis (RA) and psoriasis. Psoriasis is a chronic inflammatory skin disease characterized by epidermal hyperproliferation and differentiation. Through regulation of key transcriptional factors or signaling members, ubiquitination is viewed as a key regulator in psoriasis. Thus, targeting ubiquitination pathway holds potential for the treatment of psoriasis. Herein, we summarize the current understanding of ubiquitination in psoriasis, and discuss the prospects for targeting ubiquitination in the treatment of psoriasis. (C) 2017 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：219 / 225

页数：7

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