A general one-step synthesis of β-nitronitriles

被引：40

作者：

Anderson, James C. ^{[1
]}

Blake, Alexander J. ^{[1
]}

Mills, Matthew ^{[1
]}

Ratcliffe, Paul D. ^{[2
]}

机构：

[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

[2] Schering Plough Corp, Dept Med Chem, Glasgow, Lanark, Scotland

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 18期

关键词：

D O I：

10.1021/ol801691c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The unusual beta-nitronitrile functionality was prepared by a simple one-step hydrocyanation of nitroalkenes. These compounds were shown to be precursors to monoprotected 1,3-diamines and 1,3-amino alcohols through the in situ formation of an alpha-cyano-aldenyde.

引用

页码：4141 / 4143

页数：3

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