5-fluoro-2-methyl-N-[5-(5H-pyrrolo[2,1-c][1,4] benzodiazepine-10(11H)-YL carbonyl)-2-pyridinyl] benzamide (CL-385004) and analogs as orally active arginine vasopressin receptor antagonists

被引：16

作者：

Aranapakam, V ^{[1
]}

Albright, JD ^{[1
]}

Grosu, GT ^{[1
]}

Santos, EGD ^{[1
]}

Chan, PS ^{[1
]}

Coupet, J ^{[1
]}

Ru, X ^{[1
]}

Saunders, T ^{[1
]}

Mazandarani, H ^{[1
]}

机构：

[1] Wyeth Ayerst Res, Pearl River, NY 10965 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(99)00279-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthesis and structure-activity relationships (SAR) of orally active arginine vasopressin (AVP) receptor antagonists are discussed. Potent and orally active AVP receptor antagonists are produced when ring A of VPA-985 (1) is replaced with a 3-pyridinyl unit (2b). (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1737 / 1740

页数：4

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