Single-handed recognition of a sorting traffic motif by the GGA proteins

被引:17
作者
Kirchhausen, T [1 ]
机构
[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
[2] Ctr Blood Res, Boston, MA 02115 USA
关键词
D O I
10.1038/nsb0402-241
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Selective transport of cargo between membrane-bound organelles is vital for the well-being of cells. The crystal structure of a short peptide signal from the cytoplasmic tail of the mannose-6-phosphate receptor bound to the VHS domain of GGA proteins gives hints to how sorting works.
引用
收藏
页码:241 / 244
页数:5
相关论文
共 19 条
[1]   A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi [J].
Boman, AL ;
Zhang, CJ ;
Zhu, XJ ;
Kahn, RA .
MOLECULAR BIOLOGY OF THE CELL, 2000, 11 (04) :1241-1255
[2]   GGAs: A family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex [J].
Dell'Angelica, EC ;
Puertollano, R ;
Mullins, C ;
Aguilar, RC ;
Vargas, JD ;
Hartnell, LM ;
Bonifacino, JS .
JOURNAL OF CELL BIOLOGY, 2000, 149 (01) :81-93
[3]  
Gatto GJ, 2000, NAT STRUCT BIOL, V7, P1091
[4]   A family of proteins with γ-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome [J].
Hirst, J ;
Lui, WWY ;
Bright, NA ;
Totty, N ;
Seaman, MNJ ;
Robinson, MS .
JOURNAL OF CELL BIOLOGY, 2000, 149 (01) :67-79
[5]   Clathrin [J].
Kirchhausen, T .
ANNUAL REVIEW OF BIOCHEMISTRY, 2000, 69 :699-727
[6]   Adaptors for clathrin-mediated traffic [J].
Kirchhausen, T .
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1999, 15 :705-+
[7]   Three ways to make a vesicle [J].
Kirchhausen, T .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2000, 1 (03) :187-198
[8]   VHS domain marks a group of proteins involved in endocytosis and vesicular trafficking [J].
Lohi, O ;
Lehto, VP .
FEBS LETTERS, 1998, 440 (03) :255-257
[9]   Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains [J].
Misra, S ;
Puertollano, R ;
Kato, Y ;
Bonifacino, JS ;
Hurley, JH .
NATURE, 2002, 415 (6874) :933-937
[10]   The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein [J].
Nielsen, MS ;
Madsen, P ;
Christensen, EI ;
Nykjær, A ;
Gliemann, J ;
Kasper, D ;
Pohlmann, R ;
Petersen, CM .
EMBO JOURNAL, 2001, 20 (09) :2180-2190