Neuroinflammation and regeneration in the early stages of Alzheimer's disease pathology

被引：146

作者：

Hoozemans, JJM

Veerhuis, R

Rozemuller, JM

Eikelenboom, P

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Neuropathol, Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Neurogenet Lab, NL-1105 AZ Amsterdam, Netherlands

[3] Univ Amsterdam, Acad Med Ctr, Dept Neurol, NL-1105 AZ Amsterdam, Netherlands

[4] Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, Amsterdam, Netherlands

[5] Vrije Univ Amsterdam, Med Ctr, Clin Chem & Alzheimer Ctr, Amsterdam, Netherlands

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE | 2006年 / 24卷 / 2-3期

关键词：

amyloid beta; Alzheimer's disease; cell cycle; microglia; neuroinflammation; regeneration;

D O I：

10.1016/j.ijdevneu.2005.11.001

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The initial stages of Alzheimer's disease pathology in the neocortex show upregulation of cell cycle proteins, adhesion and inflammation related factors, indicating the early involvement of inflammatory and regenerating pathways in Alzheimer's disease pathogenesis. These brain changes precede the neurofibrillary pathology and the extensive process of neurodestruction and (astro)gliosis. Amyloid beta deposition, inflammation and regenerative mechanisms are also early pathogenic events in transgenic mouse models harbouring the pathological Alzheimer's disease mutations, while neurodegenerative characteristics are not seen in these models. This review will discuss the relationship between neuroinflammation and neuroregeneration in the early stages of Alzheimer's disease pathogenesis. (c) 2005 ISDN. Published by Elsevier Ltd. All rights reserved.

引用

页码：157 / 165

页数：9

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