3,5-Diiodo-L-thyronine ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats

被引：77

作者：

Shang, Guoguo ^{[1
]}

Gao, Pan ^{[1
]}

Zhao, Zhonghua ^{[1
]}

Chen, Qi ^{[1
]}

Jiang, Tao ^{[1
]}

Zhang, Nong ^{[1
]}

Li, Hui ^{[1
]}

机构：

[1] Fudan Univ, Sch Basic Med Sci, Dept Pathol, Shanghai 200032, Peoples R China

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2013年 / 1832卷 / 05期

基金：

中国国家自然科学基金;

关键词：

3; 5-Diiodothyronine; Diabetic nephropathy; Mesangial cells; SIRT1; NF-kappa B; JNK; INDUCED INSULIN-RESISTANCE; THYROID-HORMONE; GLUCOSE-HOMEOSTASIS; SIRT1; PROTEIN; HYPOTHYROIDISM; SENSITIVITY; INHIBITION; RECEPTOR; MICE;

D O I：

10.1016/j.bbadis.2013.01.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

3, 5-Diiodothyronine (T2), a natural metabolite of triiodothyronine (T3) from deiodination pathway, can mimic biologic effects of T3 without inducing thyrotoxic effects. Recent studies revealed T3 acted as a protective factor against diabetic nephropathy (DN). Nevertheless, little is known about the effect of 12 on DN. This study was designed to investigate whether and how T2 affects experimental models of DN in vivo and in vitro. Administration of T2 was found to prevent significant decrease in SIRT1 protein expression and activity as well as increases in blood glucose, urine albumin excretion, matrix expansion, transforming growth factor-beta 1 expression, fibronectin and type IV collagen deposition in the diabetic kidney. Concordantly, similar effects of T2 were exhibited in the cultured rat mesangial cells (RMC) exposed to high glucose and that could be abolished by a known SIRT1 inhibitor, sirtinol. Moreover, enhanced NF-KB acetylation and JNK phosphorylation present in both diabetic rats and high glucose-treated RMC were distinctly dampened by T2. Collectively, these results suggested that T2 was a protective agent against renal damage in diabetic nephropathy, whose action involved regulation of SIRT1. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：674 / 684

页数：11

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