Use of 2-tracer PET to diagnose gastrointestinal stromal tumour and pheochromocytoma in patients with Carney triad and neurofibromatosis type 1

被引:21
作者
Bümming, P
Nilsson, B [1 ]
Sörensen, J
Nilsson, O
Ahlman, H
机构
[1] Sahlgrens Univ Hosp, Dept Surg, Lundberg Lab Canc Res, SE-41345 Gothenburg, Sweden
[2] Sahlgrens Univ Hosp, Dept Pathol, Lundberg Lab Canc Res, SE-41345 Gothenburg, Sweden
[3] Univ Uppsala Hosp, Uppsala Imanet AB, Uppsala, Sweden
关键词
Carney triad; GIST; neurofibromatosis type 1; PET;
D O I
10.1080/00365520500434838
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
There is rapid evolution in the functional imaging of tumours. In two patients with concomitant pheochromocytoma and gastrointestinal stromal tumour (GIST), previously unrecognized tumours were visualized by combined 2-tracer positron emission tomography (PET), which also provided precise information about tumour type. PET imaging led to radical resection and the diagnoses were histopathologically confirmed. GISTs from the Carney patient and the patient with neurofibromatosis type 1 (NF1) both lacked KIT mutations.
引用
收藏
页码:626 / 630
页数:5
相关论文
共 11 条
[1]
Bergström M, 2000, J NUCL MED, V41, P275
[2]
Pheochromocytoma: The expanding genetic differential diagnosis [J].
Bryant, J ;
Farmer, J ;
Kessler, LJ ;
Townsend, RR ;
Nathanson, KL .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2003, 95 (16) :1196-1204
[3]
BUMMING P, 2003, P AN M AM SOC CLIN, V22, P3289
[4]
Gastric stromal sarcoma, pulmonary chondroma, and extra-adrenal paraganglioma (Carney triad): Natural history, adrenocortical component, and possible familial occurrence [J].
Carney, JA .
MAYO CLINIC PROCEEDINGS, 1999, 74 (06) :543-552
[5]
Carney triad: case report and molecular analysis of gastric tumor [J].
Diment, J ;
Tamborini, E ;
Casali, P ;
Gronchi, A ;
Carney, JA ;
Colecchia, M .
HUMAN PATHOLOGY, 2005, 36 (01) :112-116
[6]
Absence of c-kit gene mutations in gastrointestinal stromal tumours from neurofibromatosis type 1 patients [J].
Kinoshita, K ;
Hirota, S ;
Isozaki, K ;
Ohashi, A ;
Nishida, T ;
Kitamura, Y ;
Shinomura, Y ;
Matsuzawa, Y .
JOURNAL OF PATHOLOGY, 2004, 202 (01) :80-85
[7]
NEUROFIBROMATOSIS-1 (RECKLINGHAUSEN DISEASE) AND NEUROFIBROMATOSIS-2 (BILATERAL ACOUSTIC NEUROFIBROMATOSIS) - AN UPDATE [J].
MULVIHILL, JJ ;
PARRY, DM ;
SHERMAN, JL ;
PIKUS, A ;
KAISERKUPFER, MI ;
ELDRIDGE, R .
ANNALS OF INTERNAL MEDICINE, 1990, 113 (01) :39-52
[8]
OKADA E, 1984, ACTA PATHOL JAPON, V34, P425
[9]
SHULKIN BL, 1992, J NUCL MED, V33, P1125
[10]
SUZUKI S, 1910, BERL KLIN WCHNSCHR, V47, P1623