The Notch transcription activation complex makes its move

被引：34

作者：

Barrick, D

Kopan, R

机构：

[1] Johns Hopkins Univ, TC Jenkins Dept Biophys, Baltimore, MD 21218 USA

[2] Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA

来源：

CELL | 2006年 / 124卷 / 05期

关键词：

D O I：

10.1016/j.cell.2006.02.028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two papers in this issue of Cell (Nam et al., 2006; Wilson and Kovall, 2006) report the crystal structure of the Notch transcriptional activation complex. These structures show that the ANK domain of Notch is an integral part of the transcription complex and supports MAM binding, whereas the RAM domain may trigger allosteric changes in the structure needed for the derepression of transcription.

引用

收藏

页码：883 / 885

页数：3

相关论文

共 11 条

[1]

Hsieh JJD, 1996, MOL CELL BIOL, V16, P952

[2] SIGNALING DOWNSTREAM OF ACTIVATED MAMMALIAN NOTCH [J].

JARRIAULT, S ;

BROU, C ;

LOGEAT, F ;

SCHROETER, EH ;

KOPAN, R ;

ISRAEL, A .

NATURE, 1995, 377 (6547) :355-358

[3]

KOPAN R, 1994, DEVELOPMENT, V120, P2385

[4] Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA [J].

Kovall, RA ;

Hendrickson, WA .

EMBO JOURNAL, 2004, 23 (17) :3441-3451

[5] Roles of the ankyrin repeats and C-terminal region of the mouse Notch1 intracellular region [J].

Kurooka, H ;

Kuroda, K ;

Honjo, T .

NUCLEIC ACIDS RESEARCH, 1998, 26 (23) :5448-5455

[6] Anchoring Notch genetics and biochemistry: Structural analysis of the ankyrin domain sheds light on existing data [J].

Lubman, OY ;

Korolev, SV ;

Kopan, R .

MOLECULAR CELL, 2004, 13 (05) :619-626

[7] An experimentally determined protein folding energy landscape [J].

Mello, CC ;

Barrick, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (39) :14102-14107

[8] Structural requirements for assembly of the CSL•Intracellular Notch1•Mastermind-like 1 transcriptional activation complex [J].

Nam, Y ;

Weng, AP ;

Aster, JC ;

Blacklow, SC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (23) :21232-21239

[9] LAG-3 is a putative transcriptional activator in the C-elegans Notch pathway [J].

Petcherski, AG ;

Kimble, J .

NATURE, 2000, 405 (6784) :364-368

[10] Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H) [J].

Tamura, K ;

Taniguchi, Y ;

Minoguchi, S ;

Sakai, T ;

Tun, T ;

Furukawa, T ;

Honjo, T .

CURRENT BIOLOGY, 1995, 5 (12) :1416-1423