Percutaneous coronary intervention with rotational atherectomy for severely calcified unprotected left main: Immediate and two-years follow-up results

Introduction: According to current practice guidelines, coronary bypass surgery is the standard care option for unprotected left main (ULM) stenosis. However, a group of high surgical risk patients who are not eligible for coronary bypass surgery could benefit from percutaneous coronary intervention (PCI). Severe calcification hampers PCI in this setting, and rotational atherectomy (RA) could be of great help. Methods: We retrospectively analyzed a cohort of 40 patients with severely calcified ULM stenosis, not eligible for coronary artery bypass grafting, who underwent RA in our center. Results: Forty patients (mean age, 73 +/- 8 years; 26 males) with ULM stenosis were treated with RA. Twenty-seven (67%) had distal stenosis. The mean number of treated vessels was 2.38 +/- 0.74, with a mean lesion length of 30 +/- 18 mm. Abciximab was used in 12 (30%) cases and an intra-aortic balloon pump in three cases. One patient died during the procedure and another two patients died in the first 24 hr after the procedure. The major events registered after the procedure included one significant branch loss, and two minor and one major case of bleeding (the latter requiring transfusion) at the puncture point. After a median of 24.7 (IQR 19.634.3) months of follow-up, 12 cardiac deaths were recorded. Survival free of cardiac death was 71 +/- 7% and clinical guided target vessel revascularization 19.3 +/- 7% at 2 years. Conclusion: In a group of high surgical risk patients, RA on severely calcified left main stenosis is feasible and, in spite of high mortality rates, could pose the only possible effective treatment. (C) 2012 Wiley Periodicals, Inc.