Neural Differentiation and Therapeutic Potential of Adipose Tissue Derived Stem Cells

被引：46

作者：

Erba, Paolo ^{[1
,2
,3
]}

Terenghi, Giorgio ^{[3
]}

Kingham, Paul J. ^{[3
,4
]}

机构：

[1] Univ Basel Hosp, Dept Plast Reconstruct & Aesthet Surg, CH-4031 Basel, Switzerland

[2] Univ Lausanne Hosp, Dept Plast Reconstruct & Aesthet Surg, CH-4031 Basel, Switzerland

[3] Univ Manchester, Tissue Injury & Repair Grp, Blond McIndoe Labs, Manchester M13 9PT, Lancs, England

[4] Umea Univ, Sect Anat, Dept Integrat Med Biol, SE-90187 Umea, Sweden

来源：

CURRENT STEM CELL RESEARCH & THERAPY | 2010年 / 5卷 / 02期

关键词：

Nerve regeneration; adipose stem cells; nerve conduits; central nervous system; peripheral nervous system; MARROW STROMAL CELLS; PERIPHERAL-NERVE REGENERATION; MYELINATING SCHWANN-CELLS; IN-VITRO DIFFERENTIATION; BONE-MARROW; FUNCTIONAL RECOVERY; ADULT-RAT; AXONAL REGENERATION; PROGENITOR CELLS; GROWTH-FACTOR;

D O I：

10.2174/157488810791268645

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Neural tissue has historically been regarded as having poor regenerative capacity but recent advances in the growing fields of tissue engineering and regenerative medicine have opened new hopes for the treatment of nerve injuries and neurodegenerative disorders. Adipose tissue has been shown to contain a large quantity of adult stem cells (ASC). These cells can be easily harvested with low associated morbidity and because of their potential to differentiate into multiple cell types, their use has been suggested for a wide variety of therapeutic applications. In this review we examine the evidence indicating that ASC can stimulate nerve regeneration by both undergoing neural differentiation and through the release of a range of growth factors. We also discuss some of the issues that need to be addressed before ASC can be developed as an effective cellular therapy for the treatment of neural tissue disorders.

引用

页码：153 / 160

页数：8

共 117 条

[1] Neural stem cells display extensive tropism for pathology in adult brain: Evidence from intracranial gliomas [J].

Aboody, KS ;

Brown, A ;

Rainov, NG ;

Bower, KA ;

Liu, SX ;

Yang, W ;

Small, JE ;

Herrlinger, U ;

Ourednik, V ;

Black, PM ;

Breakefield, XO ;

Snyder, EY .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (23) :12846-12851

[2] Remyelination of the spinal cord following intravenous delivery of bone marrow cells [J].

Akiyama, Y ;

Radtke, C ;

Honmou, O ;

Kocsis, JD .

GLIA, 2002, 39 (03) :229-236

[3] Neuronal Differentiation Potential of Human Adipose-Derived Mesenchymal Stem Cells [J].

Anghileri, Elena ;

Marconi, Silvia ;

Pignatelli, Angela ;

Cifelli, Pierangelo ;

Galie, Mirco ;

Sbarbati, Andrea ;

Krampera, Mauro ;

Belluzzi, Ottorino ;

Bonetti, Bruno .

STEM CELLS AND DEVELOPMENT, 2008, 17 (05) :909-916

[4] In vitro differentiation of human processed lipoaspirate cells into early neural progenitors [J].

Ashjian, PH ;

Elbarbary, AS ;

Edmonds, B ;

DeUgarte, D ;

Zhu, M ;

Zuk, PA ;

Lorenz, HP ;

Benhaim, P ;

Hedrick, MH .

PLASTIC AND RECONSTRUCTIVE SURGERY, 2003, 111 (06) :1922-1931

[5] Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats - similarities to astrocyte grafts [J].

Azizi, SA ;

Stokes, D ;

Augelli, BJ ;

DiGirolamo, C ;

Prockop, DJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (07) :3908-3913

[6] Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice [J].

Barberi, T ;

Klivenyi, P ;

Calingasan, NY ;

Lee, H ;

Kawamata, H ;

Loonam, K ;

Perrier, AL ;

Bruses, J ;

Rubio, ME ;

Topf, N ;

Tabar, V ;

Harrison, NL ;

Beal, MF ;

Moore, MAS ;

Studer, L .

NATURE BIOTECHNOLOGY, 2003, 21 (10) :1200-1207

[7] Transplantation of prodrug-converting neural progenitor cells for brain tumor therapy [J].

Barresi, V ;

Belluardo, N ;

Sipione, S ;

Mudó, G ;

Cattaneo, E ;

Condorelli, DF .

CANCER GENE THERAPY, 2003, 10 (05) :396-402

[8] Skin-derived precursors generate myelinating Schwann cells that promote remyelination and functional recovery after contusion spinal cord injury [J].

Biernaskie, Jeff ;

Sparling, Joseph S. ;

Liu, Jie ;

Shannon, Casey P. ;

Plemel, Jason R. ;

Xie, Yuanyun ;

Miller, Freda D. ;

Tetzlaff, Wolfram .

JOURNAL OF NEUROSCIENCE, 2007, 27 (36) :9545-9559

[9] Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model [J].

Björklund, LM ;

Sánchez-Pernaute, R ;

Chung, SM ;

Andersson, T ;

Chen, IYC ;

McNaught, KS ;

Brownell, AL ;

Jenkins, BG ;

Wahlestedt, C ;

Kim, KS ;

Isacson, O .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (04) :2344-2349

[10] Environmental cues from CNS, PNS, and ENS cells regulate CNS progenitor differentiation [J].

Brannvall, Karin ;

Corell, Mikael ;

Forsberg-Nilsson, Karin ;

Svenningsen, Asa Fex .

NEUROREPORT, 2008, 19 (13) :1283-1289

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