Corticosterone modifies muscarinic receptor immunoreactivity in rat hippocampus

被引：6

作者：

Douma, BRK

Jansen, K

Korte, SM

Buwalda, B

Van der Zee, EA

Luiten, PGM

机构：

[1] Univ Groningen, Dept Anim Physiol, Grad Sch Behav & Cognit Neurosci, NL-9750 AA Haren, Netherlands

[2] DLO, ID, Inst Anim Sci & Hlth, Lelystad, Netherlands

来源：

NEUROSCIENCE LETTERS | 1999年 / 268卷 / 01期

关键词：

muscarinic receptor; adrenalectomy; corticosterone; glucocorticoid antagonist; mineralocorticoid antagonist;

D O I：

10.1016/S0304-3940(99)00377-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the present study we report the effect of corticosterone in the regulation of hippocampal muscarinic acetylcholine receptor immunoreactivity (mAChR-ir) expression in rats. Adrenalectomy (ADX) or a single injection of a mineralocorticoid antagonist RU-28318 (1.0 mg/100 g body weight (b.w.)) in adrenally intact rats 24 h prior to sacrifice revealed an increased mAChR-ir in hippocampal CA1 and CA3 areas. Corticosterone replacement (100 mu g/100 g b.w.) prevented the increase in mAChR-ir of ADX animals. However, glucocorticoid receptor antagonist (RU38486) treatment in adrenally intact rats failed to affect the mAChR immunolabeling, These results point to a modulation of muscarinic receptors by corticosterone that is predominantly mediated by the mineralocorticoid receptor. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：41 / 44

页数：4

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[1] AMYGDALA KINDLING-INDUCED SEIZURES SELECTIVELY IMPAIR SPATIAL MEMORY .1. BEHAVIORAL-CHARACTERISTICS AND EFFECTS ON HIPPOCAMPAL NEURONAL PROTEIN-KINASE-C ISOFORMS [J].