Males in rural Bangladeshi communities are more susceptible to chronic arsenic poisoning than females: Analyses based on urinary arsenic

被引:86
作者
Watanabe, C
Inaoka, T
Kadono, T
Nagano, M
Nakamura, S
Ushijima, K
Murayama, N
Miyazaki, K
Ohtsuka, R
机构
[1] Univ Tokyo, Grad Sch Med, Sch Int Hlth, Dept Human Ecol,Bunkyo Ku, Tokyo 1130033, Japan
[2] Kumamoto Univ, Fac Med, Dept Publ Hlth, Kumamoto, Japan
[3] Univ Tokyo, Dept Dermatol, Tokyo 113, Japan
[4] Int Med Ctr Japan, Div Technol Transfer & Evaluat, Tokyo, Japan
[5] Kumamoto Univ, Fac Literature, Sch Reg Studies, Dept Sociol, Kumamoto, Japan
[6] Niigata Univ Hlth & Welf, Dept Hlth & Nutr, Niigata, Japan
关键词
Bangladesh; chronic arsenic toxicity; dose-response relationship; groundwater contamination; keratosis; melanosis; urinary excretion;
D O I
10.2307/3454749
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Spot urine samples were collected from the inhabitants of two rural communities in northwestern Bangladesh. We compared arsenic levels in the urine samples ([As](u); n = 346) with those in water from tube wells ([As](tw); range < 1-535 mu g/L; n = 86) on an individual basis. The small variation of [As](u) within subjects and highly positive correlation with [As](tw) indicate that [As](u) is a useful indicator of exposure. Analyses of [As](u) showed that creatinine correction was necessary, that [As](u) only reflected recent exposure, and that there were substantial interindividual differences for a given [As](tw) level. To evaluate the toxic effects of arsenic exposure, we constructed a system for rating skin manifestations, which revealed distinct sex related differences. Comparison of males and females in the same households confirmed that skin manifestations were move severe in the males, and in the males of one community a dose-response relationship between [As](u) and the degree of skin manifestation was evident. The results of this study indicate that [As](u) in spot urine samples can be used as an exposure indicator for As. They suggest that there might be sex-related, and perhaps community-related, differences in the relationship between [As](u) and skin manifestations, although several confounding factors, including sunlight exposure and smoking habits, might contribute to the observed sex difference. The existence of such differences should be further confirmed and examined in other populations to identify the subpopulation is sensitive to chronic arsenic toxicity.
引用
收藏
页码:1265 / 1270
页数:6
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