C/EBPα mutations in acute myeloid leukaemias

被引:216
作者
Nerlov, C [1 ]
机构
[1] European Mol Biol Lab, Mouse Biol Programme, I-00016 Monterotondo, Italy
关键词
D O I
10.1038/nrc1363
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Specific mutations in the gene that encodes the multifunctional transcription factor C/EBPalpha are frequently associated with acute myeloid leukaemias. Are only a specific subset of the functions of C/EBPalpha therefore involved in leukaemogenesis?
引用
收藏
页码:394 / 400
页数:7
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共 57 条
  • [1] Establishment of the acute myeloid leukemia cell line Kasumi-6 from a patient with a dominant-negative mutation in the DNA-binding region of the C/EBPα gene
    Asou, H
    Gombart, AF
    Takeuchi, S
    Tanaka, H
    Tanioka, M
    Matsui, H
    Kimura, A
    Inaba, T
    Koeffler, HP
    [J]. GENES CHROMOSOMES & CANCER, 2003, 36 (02) : 167 - 174
  • [2] Ras signaling enhances the activity of C/EBPα to induce granulocytic differentiation by phosphorylation of serine 248
    Behre, G
    Singh, SM
    Liu, HT
    Bortolin, LT
    Christopeit, M
    Radomska, HS
    Rangatia, J
    Hiddemann, W
    Friedman, AD
    Tenen, DG
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (29) : 26293 - 26299
  • [3] The in vivo profile of transcription factors during neutrophil differentiation in human bone marrow
    Bjerregaard, MD
    Jurlander, J
    Klausen, P
    Borregaard, N
    Cowland, JB
    [J]. BLOOD, 2003, 101 (11) : 4322 - 4332
  • [4] Calkhoven CF, 2000, GENE DEV, V14, P1920
  • [5] DIFFERENTIATION-INDUCED GENE-EXPRESSION IN 3T3-L1 PREADIPOCYTES - CCAAT ENHANCER BINDING-PROTEIN INTERACTS WITH AND ACTIVATES THE PROMOTERS OF 2 ADIPOCYTE-SPECIFIC GENES
    CHRISTY, RJ
    YANG, VW
    NTAMBI, JM
    GEIMAN, DE
    LANDSCHULZ, WH
    FRIEDMAN, AD
    NAKABEPPU, Y
    KELLY, TJ
    LANE, MD
    [J]. GENES & DEVELOPMENT, 1989, 3 (09) : 1323 - 1335
  • [6] Down-modulation of the C/EBPα transcription factor in core binding factor acute myeloid leukemias
    Cilloni, D
    Carturan, S
    Gottardi, E
    Messa, F
    Messa, E
    Fava, M
    Diverio, D
    Guerrasio, A
    Lo-Coco, F
    Saglio, G
    [J]. BLOOD, 2003, 102 (07) : 2705 - 2706
  • [7] The amino terminal and E2F interaction domains are critical for C/EBPα-mediated induction of granulopoietic development of hematopoietic cells
    D'Alo, F
    Johansen, LM
    Nelson, EA
    Radomska, HS
    Evans, EK
    Zhang, P
    Nerlov, C
    Tenen, DG
    [J]. BLOOD, 2003, 102 (09) : 3163 - 3171
  • [8] C/EBPβ:: a major PML-RARA-responsive gene in retinoic acid-induced differentiation of APL cells
    Duprez, E
    Wagner, K
    Koch, H
    Tenen, DG
    [J]. EMBO JOURNAL, 2003, 22 (21) : 5806 - 5816
  • [9] ECTOPIC EXPRESSION OF THE CCAAT ENHANCER-BINDING PROTEIN-ALPHA PROMOTES THE ADIPOGENIC PROGRAM IN A VARIETY OF MOUSE FIBROBLASTIC CELLS
    FREYTAG, SO
    PAIELLI, DL
    GILBERT, JD
    [J]. GENES & DEVELOPMENT, 1994, 8 (14) : 1654 - 1663
  • [10] CCAAT ENHANCER BINDING-PROTEIN ACTIVATES THE PROMOTER OF THE SERUM-ALBUMIN GENE IN CULTURED HEPATOMA-CELLS
    FRIEDMAN, AD
    LANDSCHULZ, WH
    MCKNIGHT, SL
    [J]. GENES & DEVELOPMENT, 1989, 3 (09) : 1314 - 1322