Cathepsin B

被引：294

作者：

Mort, JS

Buttle, DJ

机构：

[1] SHRINERS HOSP CRIPPLED CHILDREN,JOINT DIS LAB,MONTREAL,PQ H3G 1A6,CANADA

[2] UNIV SHEFFIELD,SCH MED,DEPT HUMAN METAB & CLIN BIOCHEM,SHEFFIELD S10 2RX,S YORKSHIRE,ENGLAND

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 1997年 / 29卷 / 05期

基金：

英国医学研究理事会;

关键词：

cathepsin B; role in pathology; cysteine protease; enzyme mechanism;

D O I：

10.1016/S1357-2725(96)00152-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cathepsin B is a lysosomal cysteine protease of the papain family, It functions in intracellular protein catabolism and in certain situations may also be involved in other physiological processes, such as processing of antigens in the immune response, hormone activation and bone turnover, There is also evidence that cathepsin B is implicated in the pathology of chronic inflammatory diseases of airways and joints, and in cancer and pancreatitis, In this short review we outline the major structural features of the enzyme, and describe how these relate to its synthesis, trafficking, processing and function, (C) 1997 Elsevier Science Ltd.

引用

页码：715 / 720

页数：6

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