Signal-regulated proteins and fibroblast growth factor receptors: Comparative immunolocalization in rat retina

被引：18

作者：

Blanquet, PR ^{[1
]}

Jonet, L ^{[1
]}

机构：

[1] INSERM U450,F-75016 PARIS,FRANCE

来源：

NEUROSCIENCE LETTERS | 1996年 / 214卷 / 2-3期

关键词：

neural retina; immunostaining; signalling proteins; fibroblast growth factor receptor; rat;

D O I：

10.1016/0304-3940(96)12921-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We compared the immunolocalization of fibroblast growth factor (FGF)-R1 and FGF-R2 with that of several intracellular signalling proteins in rat neural retina. Only the serine/threonine extracellular signal-related kinases (ERK) and lipocortin/annexin 6, a major calcium-binding protein, appeared to be co-localized with FGF-R1 and FGF-R2 in all subfields of the neural retina. In particular, ERK appeared to be present in perikarya of ganglion cells and synaptic layers as did these receptors. Possible implications of these results with regard to neuroprotective role of FGF are discussed.

引用

页码：135 / 138

页数：4

共 22 条

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