SAMHD1-mediated HIV-1 restriction in cells does not involve ribonuclease activity

被引：79

作者：

Antonucci, Jenna M. ^{[1
,2
]}

St Gelais, Corine ^{[1
]}

de Silva, Suresh ^{[1
,6
]}

Yount, Jacob S. ^{[3
]}

Tang, Chenxiang ^{[4
]}

Ji, Xiaoyun ^{[4
]}

Shepard, Caitlin ^{[5
]}

Xiong, Yong ^{[4
]}

Kim, Baek ^{[5
]}

Wu, Li ^{[1
,2
,3
]}

机构：

[1] Ohio State Univ, Dept Vet Biosci, Ctr Retrovirus Res, Columbus, OH 43210 USA

[2] Ohio State Univ, Dept Microbiol, 484 W 12th Ave11, Columbus, OH 43210 USA

[3] Ohio State Univ, Dept Microbial Infect & Immun, Columbus, OH 43210 USA

[4] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT USA

[5] Emory Univ, Ctr Drug Discovery, Sch Med, Dept Pediat, Atlanta, GA USA

[6] Heat Biol, Durham, NC USA

来源：

NATURE MEDICINE | 2016年 / 22卷 / 10期

关键词：

DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE; CD4(+) T-CELLS; SAMHD1; RESTRICTS; NUCLEASE ACTIVITY; INFECTION; PHOSPHORYLATION; INHIBITION; PROTEIN; ACTIVATION; DGTP;

D O I：

10.1038/nm.4163

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

引用

页码：1072 / 1074

页数：3

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