Inflammatory Proteins and the Severity of Dilated Virchow-Robin Spaces in the Elderly

被引：31

作者：

Satizabal, Claudia L. ^{[2
,3
]}

Zhu, Yi-Cheng ^{[4
]}

Dufouil, Carole ^{[2
]}

Tzourio, Christophe ^{[1
,2
]}

机构：

[1] Univ Bordeaux 2, INSERM U708, F-33076 Bordeaux, France

[2] INSERM U708 Neuroepidemiol, Bordeaux, France

[3] Univ Paris 06, Paris, France

[4] Peking Union Med Coll Hosp, Dept Neurol, Beijing, Peoples R China

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2013年 / 33卷 / 02期

关键词：

Aged; cerebral small vessel diseases; dilated Virchow-Robin spaces; inflammation; magnetic resonance imaging; C-REACTIVE PROTEIN; ENLARGED PERIVASCULAR SPACES; SMALL VESSEL DISEASE; BRAIN; RISK; MRI; MARKERS; MORTALITY; FAILURE; AGE;

D O I：

10.3233/JAD-2012-120874

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent studies suggest dilated Virchow-Robin Spaces (dVRS) could be a manifestation of cerebral small-vessel disease, but little is known about their risk factors. As inflammation has been associated with other brain MRI findings, we investigated whether interleukin-6 and C-reactive protein were associated with the severity of dVRS in the eldery. dVRS were assessed in basal ganglia and white matter and rated on a severity scale. We found that elevated interleukin-6 levels were associated with higher severity of dVRS in basal ganglia, suggesting that inflammation might be associated with the burden of dVRS in the elderly.

引用

页码：323 / 328

页数：6

共 33 条

[1] Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology [J].

Abbott, NJ .

NEUROCHEMISTRY INTERNATIONAL, 2004, 45 (04) :545-552

[2] Vascular factors and risk of dementia: Design of the three-city study and baseline characteristics of the study population [J].

Alperovitch, A .

NEUROEPIDEMIOLOGY, 2003, 22 (06) :316-325

[3] Statins reduce interleukin-6-induced C-reactive protein in human hepatocytes - New evidence for direct antiinflammatory effects of statins [J].

Arnaud, C ;

Burger, F ;

Steffens, S ;

Veillard, NR ;

Nguyen, TH ;

Trono, D ;

Mach, F .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (06) :1231-1236

[4] Inflammatory markers and onset of cardiovascular events - Results from the Health ABC study [J].

Cesari, M ;

Penninx, BWJH ;

Newman, AB ;

Kritchevsky, SB ;

Nicklas, BJ ;

Sutton-Tyrrell, K ;

Rubin, SM ;

Ding, JZ ;

Simonsick, EM ;

Harris, TB ;

Pahor, M .

CIRCULATION, 2003, 108 (19) :2317-2322

[5] Enlarged Perivascular Spaces on MRI Are a Feature of Cerebral Small Vessel Disease [J].

Doubal, Fergus N. ;

MacLullich, Alasdair M. J. ;

Ferguson, Karen J. ;

Dennis, Martin S. ;

Wardlaw, Joanna M. .

STROKE, 2010, 41 (03) :450-454

[6] Biomarkers of inflammation and MRI-defined small vessel disease of the brain - The Cardiovascular Health Study [J].

Fornage, Myriam ;

Chiang, Y. Aron ;

O'Meara, Ellen S. ;

Psaty, Bruce M. ;

Reiner, Alexander P. ;

Siscovick, David S. ;

Tracy, Russell P. ;

Longstreth, W. T., Jr. .

STROKE, 2008, 39 (07) :1952-1959

[7] COMPARISON OF POSTMORTEM MAGNETIC-RESONANCE-IMAGING AND NEUROPATHOLOGIC FINDINGS IN THE CEREBRAL WHITE MATTER [J].

GRAFTON, ST ;

SUMI, SM ;

STIMAC, GK ;

ALVORD, EC ;

SHAW, CM ;

NOCHLIN, D .

ARCHIVES OF NEUROLOGY, 1991, 48 (03) :293-298

[8] Virchow-Robin spaces on magnetic resonance images: normative data, their dilatation, and a review of the literature [J].

Groeschel, Samuel ;

Chong, Wui Khean ;

Surtees, Robert ;

Hanefeld, Folker .

NEURORADIOLOGY, 2006, 48 (10) :745-754

[9]

HEIER LA, 1989, AM J NEURORADIOL, V10, P929

[10] Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFκB-C/EBP-β complex formation [J].

Kleemann, R ;

Gervois, PR ;

Verschuren, L ;

Staels, B ;

Princen, HMG ;

Kooistra, T .

BLOOD, 2003, 101 (02) :545-551

← 1 2 3 4 →