Decreased NGFI-A gene expression in the hippocampus of cognitively impaired aged rats

被引：29

作者：

Yau, JLW

Olsson, T

Morris, RGM

Noble, J

Seckl, JR

机构：

[1] UMEA UNIV, DEPT MED, UMEA, SWEDEN

[2] UNIV EDINBURGH, CTR NEUROSCI, EDINBURGH EH8 9LE, MIDLOTHIAN, SCOTLAND

来源：

MOLECULAR BRAIN RESEARCH | 1996年 / 42卷 / 02期

基金：

英国惠康基金;

关键词：

spatial memory; NGFI-A; hippocampus; water maze; gene expression; glucacorticoid receptor;

D O I：

10.1016/S0169-328X(96)00220-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Hippocampal NGFI-A gene expression is increased following the induction of long-term potentiation, a form of activity-dependent synaptic plasticity that has been implicated in learning. In this study, we show a positive correlation between spatial learning and the constitutive expression of NGFI-A mRNA, selectively in CA1 pyramidal neurons. NGFI-A mRNA expression decreased with age in CA1, CA2 and neocortex. Long-term amitriptyline treatment, which improved spatial learning in young rats, had no significant effects on NGFI-A mRNA levels. Whether hippocampal NGFI-A plays a direct role in the mechanism of learning and memory remains to be determined.

引用

收藏

页码：354 / 357

页数：4

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