Translational controls impinging on the 5'-untranslated region and initiation factor proteins

被引:69
作者
Jackson, RJ [1 ]
Wickens, M [1 ]
机构
[1] UNIV WISCONSIN, DEPT BIOCHEM, MADISON, WI 53706 USA
基金
英国惠康基金;
关键词
D O I
10.1016/S0959-437X(97)80133-5
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Translation of eukaryotic mRNAs is generally initiated by the scanning ribosome mechanism. This can be downregulated by high affinity protein binding to cap-proximal RNA motifs. Translation can also be regulated by short open reading frames within the 5'-untranslated region. A key factor for initiation is eIF4F, in which one of the polypeptide chains, eIF4G, seems to have a bridging function and binds three other factors at separate sites: eIF4E (the cap-binding factor), the helicase eIF4A, and eIF3, which also interacts with 40S ribosomal subunits. Initiation is regulated by the MAP kinase and rapamycin-sensitive signalling pathways, which control phosphorylation of eIF4E and 4E-BP1, a protein which in the dephosphorylated form binds and sequesters eIF4E.
引用
收藏
页码:233 / 241
页数:9
相关论文
共 71 条
  • [1] THE SACCHAROMYCES-CEREVISIAE TRANSLATION INITIATION-FACTOR TIF3 AND ITS MAMMALIAN HOMOLOG, ELF-4B, HAVE RNA ANNEALING ACTIVITY
    ALTMANN, M
    WITTMER, B
    METHOT, N
    SONENBERG, N
    TRACHSEL, H
    [J]. EMBO JOURNAL, 1995, 14 (15) : 3820 - 3827
  • [2] Azpiazu I, 1996, J BIOL CHEM, V271, P5033
  • [3] TOR controls translation initiation and early G1 progression in yeast
    Barbet, NC
    Schneider, U
    Helliwell, SB
    Stansfield, I
    Tuite, MF
    Hall, MN
    [J]. MOLECULAR BIOLOGY OF THE CELL, 1996, 7 (01) : 25 - 42
  • [4] Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation
    Beretta, L
    Gingras, AC
    Svitkin, YV
    Hall, MN
    Sonenberg, N
    [J]. EMBO JOURNAL, 1996, 15 (03) : 658 - 664
  • [5] THE TRANSLATIONAL REPRESSION MEDIATED BY THE PLATELET-DERIVED GROWTH-FACTOR 2/C-SIS MESSENGER-RNA LEADER IS RELIEVED DURING MEGAKARYOCYTIC DIFFERENTIATION
    BERNSTEIN, J
    SHEFLER, I
    ELROYSTEIN, O
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (18) : 10559 - 10565
  • [6] TRANSLATIONAL INHIBITION BY A HUMAN CYTOMEGALOVIRUS UPSTREAM OPEN READING FRAME DESPITE INEFFICIENT UTILIZATION OF ITS AUG CODON
    CAO, JH
    GEBALLE, AP
    [J]. JOURNAL OF VIROLOGY, 1995, 69 (02) : 1030 - 1036
  • [7] Cao JH, 1996, MOL CELL BIOL, V16, P603
  • [8] INITIATION OF PROTEIN-SYNTHESIS BY THE EUKARYOTIC TRANSLATIONAL APPARATUS ON CIRCULAR RNAS
    CHEN, CY
    SARNOW, P
    [J]. SCIENCE, 1995, 268 (5209) : 415 - 417
  • [9] ISOLATION OF A PROTEIN COMPLEX CONTAINING TRANSLATION INITIATION-FACTOR PRT1 FROM SACCHAROMYCES-CEREVISIAE
    DANAIE, P
    WITTMER, B
    ALTMANN, M
    TRACHSEL, H
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (09) : 4288 - 4292
  • [10] DEVER TE, 1995, MOL CELL BIOL, V15, P6351