Bio-based Biodegradable and Biocompatible Hyperbranched Polyurethane: A Scaffold for Tissue Engineering

被引：52

作者：

Das, Beauty ^{[1
]}

Chattopadhyay, Pronobesh ^{[2
]}

Mandal, Manabendra

Voit, Brigitte ^{[3
]}

Karak, Niranjan ^{[1
]}

机构：

[1] Tezpur Univ, Adv Polymer & Nanomat Lab, Dept Chem Sci, Tezpur 784028, India

[2] Def Res Lab, Tezpur 784001, Assam, India

[3] Leibniz Inst Polymer Res Dresden, D-01069 Dresden, Germany

来源：

MACROMOLECULAR BIOSCIENCE | 2013年 / 13卷 / 01期

关键词：

bio-based hyperbranched polyurethanes; biocompatibility; biodegradable; cytocompatible; tunable properties; POLYMERS; BIOMATERIALS; POLYESTERS; CACHECTIN;

D O I：

10.1002/mabi.201200244

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Hyperbranched polyurethanes are synthesized using TDI, PCL diol, butanediol, and pentaerythritol (15?wt%) as the B4 reactant with and without the monoglyceride of sunflower oil. The biodegradation, physico-mechanical, and thermal properties are found to be tailored by varying the percentage weight of the branching unit. An MTT/hemolytic assay and subcutaneous implantation in Wistar rats followed by cytokine/ALP assay and histopathology studies confirm a better biocompatibility of HBPU with MG than without MG. HBPU supports the proliferation of dermatocytes with no toxic effect in major organs, in addition the in vitro degraded products are non-toxic. Cell adherence and proliferation endorse the bio-based HBPU as a prospective scaffold material in the niche of tissue engineering.

引用

页码：126 / 139

页数：14

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