Visible light activatable binary system of oligonucleotide conjugates for nucleic acids modification

被引：8

作者：

Dobrikov, MI ^{[1
]}

Gainutdinov, TI ^{[1
]}

Vlassov, VV ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Bioorgan Chem, Novosibirsk 630090, Russia

来源：

NUCLEOSIDES & NUCLEOTIDES | 1999年 / 18卷 / 6-7期

关键词：

D O I：

10.1080/07328319908044773

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A binary system of oligonucleotides conjugated to perfluoroarylazide and perylene for sequence-specific photomodification of nucleic acids has been developed. The system can be activated by visible light (450-580 nm), reacts 300000 times faster than azide in the absence of perylene and provides highly efficient (up to 99%) photomodification of target ssDNA.

引用

页码：1517 / 1518

页数：2