Acute coronary syndromes: should women receive less antithrombotic medication than men?

被引:3
作者
Danchin, N [1 ]
机构
[1] Hop Europeen Georges Pompidou, F-75015 Paris, France
关键词
D O I
10.1136/hrt.2002.003483
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A recent meta-analysis of all randomised trials assessing the efficacy and safety of glycoprotein IIb/IIIa agents with acute coronary syndromes showed that there was a significant interaction with sex. Explaining this difference requires an analysis of whether it has any pathophysiological basis, whether antithrombotic medications are indeed less efficacious in women in different clinical situations, and whether there are any specific reasons that may have led to the provocative results of the meta-analysis.
引用
收藏
页码:363 / 366
页数:4
相关论文
共 23 条
[1]   MODULATION OF VASOPRESSIN ACTIONS ON HUMAN PLATELETS BY PLASMA ADENOSINE AND THEOPHYLLINE - GENDER DIFFERENCES [J].
AGARWAL, KC .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1993, 21 (06) :1012-1018
[2]   INDICATIONS FOR FIBRINOLYTIC THERAPY IN SUSPECTED ACUTE MYOCARDIAL-INFARCTION - COLLABORATIVE OVERVIEW OF EARLY MORTALITY AND MAJOR MORBIDITY RESULTS FROM ALL RANDOMIZED TRIALS OF MORE THAN 1000 PATIENTS [J].
APPLEBY, P ;
BAIGENT, C ;
COLLINS, R ;
FLATHER, M ;
PARISH, S ;
PETO, R ;
BELL, P ;
HALLS, H ;
MEAD, G ;
DIAZ, R ;
PAOLASSO, E ;
PAVIOTTI, C ;
ROMERO, G ;
CAMPBELL, T ;
OROURKE, MF ;
THOMPSON, P ;
LESAFFRE, E ;
VANDEWERF, F ;
VERSTRAETE, M ;
ARMSTRONG, PW ;
CAIRNS, JA ;
MORAN, C ;
TURPIE, AG ;
YUSUF, S ;
GRANDE, P ;
HEIKKILA, J ;
KALA, R ;
BASSAND, JP ;
BOISSEL, JP ;
BROCHIER, M ;
LEIZOROVICZ, A ;
BRUGGEMANN, T ;
KARSCH, KR ;
KASPER, W ;
LAMMERTS, D ;
NEUHAUS, KL ;
MEYER, J ;
SCHRODER, R ;
VONESSEN, R ;
SARAN, RK ;
ARDISSINO, D ;
BONADUCE, D ;
BRUNELLI, C ;
CERNIGLIARO, C ;
FORESTI, A ;
FRANZOSI, MG ;
GUIDUCCI, D ;
MAGGIONI, A ;
MAGNANI, B ;
MATTIOLI, G .
LANCET, 1994, 343 (8893) :311-322
[3]   Influence of patient characteristics and renal function on factor Xa inhibition pharmacokinetics and pharmacodynamics after enoxaparin administration in non-ST-segment elevation acute coronary syndromes [J].
Becker, RC ;
Spencer, FA ;
Gibson, M ;
Rush, JE ;
Sanderink, G ;
Murphy, SA ;
Ball, SP ;
Antman, EM .
AMERICAN HEART JOURNAL, 2002, 143 (05) :753-759
[4]   Management of acute coronary syndromes in patients presenting without persistent ST-segment elevation [J].
Bertrand, ME ;
Simoons, ML ;
Fox, KAA ;
Wallentin, LC ;
Hamm, CW ;
McFadden, E ;
De Feyter, PJ ;
Specchia, G ;
Ruzyllo, W .
EUROPEAN HEART JOURNAL, 2002, 23 (23) :1809-1840
[5]   Platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes:: a meta-analysis of all major randomised clinical trials [J].
Boersma, E ;
Harrington, RA ;
Moliterno, DJ ;
White, H ;
Théroux, P ;
Van de Werf, F ;
de Torbal, A ;
Armstrong, PW ;
Wallentin, LC ;
Wilcox, RG ;
Simes, J ;
Califf, RM ;
Topol, EJ ;
Simoons, ML .
LANCET, 2002, 359 (9302) :189-198
[6]   Clinical benefit of glycoprotein IIb/IIIa blockade with abciximab is independent of gender - Pooled analysis from EPIC, EPILOG and EPISTENT trials [J].
Cho, L ;
Topol, EJ ;
Balog, C ;
Foody, JM ;
Booth, JE ;
Cabot, C ;
Kleiman, NS ;
Tcheng, JE ;
Califf, R ;
Lincoff, MA .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2000, 36 (02) :381-386
[7]  
Danielsen R, 1998, SCAND CARDIOVASC J, V32, P87
[8]   Aspirin-resistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular events [J].
Eikelboom, JW ;
Hirsh, J ;
Weitz, JI ;
Johnston, M ;
Yi, Q ;
Yusuf, S .
CIRCULATION, 2002, 105 (14) :1650-1655
[9]  
Faraday N, 1997, THROMB HAEMOSTASIS, V77, P748
[10]   Is glycoprotein IIb/IIIa antagonism as effective in women as in men following percutaneous coronary intervention? Lessons from the ESPRIT study [J].
Fernandes, LS ;
Tcheng, JE ;
O'Shea, JC ;
Weiner, B ;
Lorenz, TJ ;
Pacchiana, C ;
Berdan, LG ;
Maresh, KJ ;
Joseph, D ;
Madan, M ;
Mann, T ;
Kilaru, R ;
Hochman, JS ;
Kleiman, NS .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 40 (06) :1085-1091