Single channel properties of ATP-gated cation channels (P2X receptors) heterologously expressed in Chinese hamster ovary cells

被引：49

作者：

Evans, RJ ^{[1
]}

机构：

[1] GLAXO WELLCOME RES & DEV SA,GENEVA BIOMED RES INST,CH-1228 PLAN LES OUATES,GENEVA,SWITZERLAND

来源：

NEUROSCIENCE LETTERS | 1996年 / 212卷 / 03期

关键词：

ion channels; P2X receptors; purinergic;

D O I：

10.1016/0304-3940(96)12804-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The single channel properties of four P2X receptors heterologously expressed in Chinese hamster ovary cells were determined from outside-out patch recordings. P2X(1) and P2X(4) channels opened in brief flickery bursts with conductances of similar to 18 and 9 pS respectively. P2X(2) receptors had a single channel conductance of similar to 21 pS. Openings of P2X(3) channels were too rapid to be reliably resolved. Application of ATP to macro-patches expressing multiple P2X(2) or P2X(4) receptors evoked sustained currents, in contrast responses of P2X(1) or P2X(3) receptors desensitised during continued agonist application. These data show that four different homomeric P2X receptors form ion channels with distinct single channel properties.

引用

页码：212 / 214

页数：3

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