Regeneration and tolerance factor: A novel mediator of glioblastoma-associated immunosuppression

被引：19

作者：

Roth, P

Aulwurm, S

Gekel, I

Beier, D

Sperry, RG

Mittelbronn, M

Meyermann, R

Beaman, KD

Weller, M

Wischhusen, J

机构：

[1] Univ Tubingen, Sch Med, Dept Gen Neurol, Hertie Inst Clin Brain Res,Lab Mol Neurooncol, D-72076 Tubingen, Germany

[2] Univ Tubingen, Sch Med, Brain Res Inst, D-72076 Tubingen, Germany

[3] Rosalind Franklin Univ Med & Sci, Dept Microbiol Immunol, Clin Immunol Lab, N Chicago, IL USA

来源：

CANCER RESEARCH | 2006年 / 66卷 / 07期

关键词：

D O I：

10.1158/0008-5472.CAN-05-3062

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Regeneration and tolerance factor (RTF) was originally identified in placenta where it is thought to be essential for fetal allograft survival. Here we report that RTF mRNA and protein are also expressed in human glioma cells in vitro and in vivo. Suppression of RTF expression by RNA interference promotes the lysis of glioma cells by natural killer (NK) and T cells in vitro. Moreover, RTF-depleted glioma cells are less tumorigenic than control cells in nude mice in vivo. Depletion of NK cells in these animals abolished this effect. RTF is thus a novel aberrantly expressed molecule which confers immune privilege to human malignant gliomas.

引用

页码：3852 / 3858

页数：7

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