Two 6-substituted 5,6-dihydro-α-pyrones from Ravensara anisata

被引：31

作者：

Andrianaivoravelona, JO

Sahpaz, S

Terreaux, C

Hostettmann, K ^{[1
]}

Stoeckli-Evans, H

Rasolondramanitra, J

机构：

[1] Ecole Polytech Fed Lausanne, Inst Pharmacognosie & Phytochim, BEP, CH-1015 Lausanne, Switzerland

[2] Ctr Natl Rech Ind & Technol, Antananarivo 101, Madagascar

[3] Univ Neuchatel, Inst Chim, CH-2000 Neuchatel, Switzerland

[4] Ecole Super Polytech, Antananarivo 101, Madagascar

来源：

PHYTOCHEMISTRY | 1999年 / 52卷 / 02期

关键词：

Ravensara anisata; Lauraceae; antifungal activity; Cladosporium cucumerinum; Candida albicans; alpha-pyrones; X-ray analysis;

D O I：

10.1016/S0031-9422(99)00158-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The leaves and bark dichloromethane extracts of Ravensara anisata showed antifungal activity against the yeast Candida albicans and the phytopathogenic fungus Cladosporium cucumerinum in bioautographic TLC assays. Activity-guided fractionation afforded two new alpha-pyrones: 6R(*)-(4R(*)-acetoxy-2S(*)-hydroxy-8-phenyloctyl)-5, 6-dihydro-2-H-pyran-2-one and 6R(*)(2S(*)-acetoxy-4R(*)-hydroxy-8-phenyloctyl)-5,6-dihydro-2-H-pyran-2-one. Their structures have been established by NMR spectroscopy, chemical methods and X-ray crystallographic analysis. The antifungal activity against C. albicans and C. cucumerinum was determined for both compounds. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：265 / 269

页数：5

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