Exosomal microRNAs (exomiRs): Small molecules with a big role in cancer

被引：177

作者：

Bhome, Rahul ^{[1
,2
]}

Del Vecchio, Filippo ^{[1
]}

Lee, Gui-Han ^{[1
,2
]}

Bullock, Marc D. ^{[1
,2
]}

Primrose, John N. ^{[2
]}

Sayan, A. Emre ^{[1
]}

Mirnezami, Alex H. ^{[1
,2
]}

机构：

[1] Univ Southampton, Canc Sci, Southampton, Hants, England

[2] Univ Southampton, Univ Surg Unit, Southampton, Hants, England

来源：

CANCER LETTERS | 2018年 / 420卷

基金：

英国医学研究理事会;

关键词：

exomiR; exosome; microRNA; cancer biomarker; CELL-DERIVED EXOSOMES; BREAST-CANCER; MULTIVESICULAR BODIES; INTERCELLULAR TRANSFER; DIAGNOSTIC BIOMARKERS; MEMBRANE-VESICLES; MELANOMA EXOSOMES; SMALL RNAS; MIRNA; MICROVESICLES;

D O I：

10.1016/j.canlet.2018.02.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Exosomes are secreted vesicles which can transmit molecular cargo between cells. Exosomal microRNAs (exomiRs) have drawn much attention in recent years because there is increasing evidence to suggest that loading of microRNAs into exosomes is not a random process. Preclinical studies have identified functional roles for exomiRs in influencing many hallmarks of cancer. Mechanisms underpinning their actions, such as exomiR receptors ("miRceptors"), are now becoming apparent. Even more exciting is the fact that exomiRs are highly suitable candidates for use as non-invasive biomarkers in an era of personalized cancer medicine. (C) 2018 The Authors. Published by Elsevier B.V.

引用

页码：228 / 235

页数：8

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