The acute respiratory distress syndrome

被引：1514

作者：

Matthay, Michael A. ^{[1
,2
,3
]}

Ware, Lorraine B. ^{[4
]}

Zimmerman, Guy A. ^{[5
]}

机构：

[1] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Anesthesia, San Francisco, CA 94143 USA

[4] Vanderbilt Univ, Dept Med, Div Allergy Pulm & Crit Care Med, Nashville, TN USA

[5] Univ Utah, Dept Med, Div Pulm & Crit Care Med, Salt Lake City, UT 84112 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2012年 / 122卷 / 08期

关键词：

ACUTE LUNG INJURY; RANDOMIZED CONTROLLED-TRIAL; END-EXPIRATORY PRESSURE; MESENCHYMAL STEM-CELLS; ALVEOLAR EPITHELIAL-CELLS; NEUTROPHIL EXTRACELLULAR TRAPS; CHRONIC ALCOHOL-ABUSE; PULMONARY-EDEMA; CLINICAL-OUTCOMES; TIDAL VOLUME;

D O I：

10.1172/JCI60331

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The acute respiratory distress syndrome (ARDS) is an important cause of acute respiratory failure that is often associated with multiple organ failure. Several clinical disorders can precipitate ARDS, including pneumonia, sepsis, aspiration of gastric contents, and major trauma. Physiologically, ARDS is characterized by increased permeability pulmonary edema, severe arterial hypoxemia, and impaired carbon dioxide excretion. Based on both experimental and clinical studies, progress has been made in understanding the mechanisms responsible for the pathogenesis and the resolution of lung injury, including the contribution of environmental and genetic factors. Improved survival has been achieved with the use of lung-protective ventilation. Future progress will depend on developing novel therapeutics that can facilitate and enhance lung repair.

引用

页码：2731 / 2740

页数：10

共 150 条

[1] Liposomal prostaglandin E1 (TLC C-53) in acute respiratory distress syndrome:: A controlled, randomized, double-blind, multicenter clinical trial [J].

Abraham, E ;

Baughman, R ;

Fletcher, E ;

Heard, S ;

Lamberti, J ;

Levy, H ;

Nelson, L ;

Rumbak, M ;

Steingrub, J ;

Taylor, J ;

Park, YC ;

Hynds, JM ;

Freitag, J .

CRITICAL CARE MEDICINE, 1999, 27 (08) :1478-1485

[2]

ADAMSON IYR, 1974, LAB INVEST, V30, P35

[3] Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome [J].

Albertine, KH ;

Soulier, MF ;

Wang, ZM ;

Ishizaka, A ;

Hashimoto, S ;

Zimmerman, GA ;

Matthay, MA ;

Ware, LB .

AMERICAN JOURNAL OF PATHOLOGY, 2002, 161 (05) :1783-1796

[4] Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome [J].

Amato, MBP ;

Barbas, CSV ;

Medeiros, DM ;

Magaldi, RB ;

Schettino, GDP ;

Lorenzi, G ;

Kairalla, RA ;

Deheinzelin, D ;

Munoz, C ;

Oliveira, R ;

Takagaki, TY ;

Carvalho, CRR .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (06) :347-354

[5]

[Anonymous], 2000, N ENGL J MED, V342, P1301

[6]

ASHBAUGH DG, 1967, LANCET, V2, P319

[7] ALTERATIONS OF GAS-EXCHANGE APPARATUS IN ADULT RESPIRATORY INSUFFICIENCY ASSOCIATED WITH SEPTICEMIA [J].

BACHOFEN, M ;

WEIBEL, ER .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1977, 116 (04) :589-615

[8] Procoagulant alveolar microparticles in the lungs of patients with acute respiratory distress syndrome [J].

Bastarache, Julie A. ;

Fremont, Richard D. ;

Kropski, Jonathan A. ;

Bossert, Frederick R. ;

Ware, Lorraine B. .

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2009, 297 (06) :L1035-L1041

[9] A trial of antioxidants N-acetylcysteine and procysteine in ARDS [J].

Bernard, GR ;

Wheeler, AP ;

Arons, MM ;

Morris, PE ;

Paz, HL ;

Russell, JA ;

Wright, PE ;

Bernard, GR ;

Arons, MM ;

Wheeler, AP ;

Carmichael, LC ;

Morris, PE ;

Higgins, SB ;

Dupont, WD ;

Edens, TR ;

Swindell, BB ;

Russell, JA ;

Paz, HL ;

Wright, PE ;

Steinberg, KP .

CHEST, 1997, 112 (01) :164-172

[10] THE AMERICAN-EUROPEAN CONSENSUS CONFERENCE ON ARDS - DEFINITIONS, MECHANISMS, RELEVANT OUTCOMES, AND CLINICAL-TRIAL COORDINATION [J].

BERNARD, GR ;

ARTIGAS, A ;

BRIGHAM, KL ;

CARLET, J ;

FALKE, K ;

HUDSON, L ;

LAMY, M ;

LEGALL, JR ;

MORRIS, A ;

SPRAGG, R ;

COCHIN, B ;

LANKEN, PN ;

LEEPER, KV ;

MARINI, J ;

MURRAY, JF ;

OPPENHEIMER, L ;

PESENTI, A ;

REID, L ;

RINALDO, J ;

VILLAR, J ;

VANASBECK, BS ;

DHAINAUT, JF ;

MANCEBO, J ;

MATTHAY, M ;

MEYRICK, B ;

PAYEN, D ;

PERRET, C ;

FOWLER, AA ;

SCHALLER, MD ;

HUDSON, LD ;

HYERS, T ;

KNAUS, W ;

MATTHAY, R ;

PINSKY, M ;

BONE, RC ;

BOSKEN, C ;

JOHANSON, WG ;

LEWANDOWSKI, K ;

REPINE, J ;

RODRIGUEZROISIN, R ;

ROUSSOS, C ;

ANTONELLI, MA ;

BELOUCIF, S ;

BIHARI, D ;

BURCHARDI, H ;

LEMAIRE, F ;

MONTRAVERS, P ;

PETTY, TL ;

ROBOTHAM, J ;

ZAPOL, W .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1994, 149 (03) :818-824

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